Critical Micelle Concentration ( CMC ) Determination - Unknown - Unknown - Unknown

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SupportingInformationTowardsDevelopingDiscriminatingDissolutionMethodsforFormulationsContainingNano-ParticulatesinSolution;TheImpactofParticleDriftandDrugActivityinSolutionFreddyA.Arce†@,NicoSetiawan‡@,HeatherR.Campbell†,XingyuLu¶@,MatthewJ.Nethercott§,PaulBummer†,YongchaoSu,¶,andPatrickJ.Marsac∗,††DepartmentofPharmaceuticalSciences,CollegeofPharmacy,UniversityofKentucky,Lexington,Kentucky,USA40536‡AlbanyMolecularResearchInc.,WestLafayette,Indiana,USA47906¶PharmaceuticalSciences,Merck&Co.,Kenilworth,NewJersey,USA07033§KeyLaboratoryofPreciseSynthesisofFunctionalMoleculesofZhejiangProvince,SchoolofScience,WestlakeUniversity,Hangzhou,Zhejiang,China310024KansasAnalyticalServices,LLC,Loveland,Colorado,USA80537DivisionofMolecularPharmaceuticsandDrugDelivery,CollegeofPharmacy,TheUniversityofTexasatAustin,Austin,Texas,USA78712#DepartmentofIndustrialandPhysicalPharmacy,CollegeofPharmacy,PurdueUniversity,WestLafayette,Indiana,USA47907@Co-FirstAuthors*CorrespondingAuthor:patrick.marsac@uky.edu

1FigureS1:Observedsurfacetensiondataof20mMPhosphateBuffer(pH=6.8)and5ug/mLHPMCsolutionscontainingvaryingconcentrationsofPolysorbate80.CriticalMicelleConcentration(CMC)Determination60)SurfaceTensionPre-Micelle/mNSurfaceTensionPost-Micelle(m50niosneTe40carfuS300101011.1100.00.000.00.000[PS80](mM)UsingSemi-logleastsquaresregressionfittingtheequationsdescribingthesurfacetensionbeforeandaftertheformationofmicellesareY=-7.428*Log(X)+29.05andY=-4.112*Log(X)+35.28respectively.ThetwolinesintersectatLog(X)=-1.88,whichcorrespondstoacriticalmicelleconcentrationof0.013mM.FigureS2:Observedfluxof17-Estradiolinside-bi-sidediffusioncellsstirredat100RPMplottedasafunctionofthefractionoftheamorphoussolubility.Thefractionofamorphoussolubilityisameasureofthedegreeofsupersaturationinducedindonorsideoftheside-bi-sidediffusioncell.1.5)2m1.0/c/hg(ux0.5luFY=1.360x+0.0000.00.00.20.40.60.81.0FractionofAmorphousSolubility

2FigureS3:Observedfluxof17-Estradiolinside-bi-sidediffusioncellsstirredat300RPMplottedasafunctionofthefractionoftheamorphoussolubility.Thefractionofamorphoussolubilityisameasureofthedegreeofsupersaturationinducedindonorsideoftheside-bi-sidediffusioncell.2.0)21.5m/c/hg1.0(uxluF0.5Y=1.523x+0.0000.00.00.20.40.60.81.0FractionofAmorphousSolubility