Metabolomics study revealing the potential risk and predictive value of - Li et al. - Unknown - Unknown

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SupportingInformationMetabolomicsstudyrevealingthepotentialriskandpredictivevalueoffragmentedQRSforacutemyocardialinfarctionJiankangLi1,WentingDuan2,LinWang3,YiqingLu2,ZhaozhaoShi2,TingliLu4*1.InstituteofMedicalResearch,NorthwesternPolytechnicalUniversity,127WestYouyiRoad,Xi'an,Shaanxi710072,China.2.DepartmentofCardiology,Xi’anNo.1Hospital,Shaanxi,Xi’an710002,China.3.DepartmentofClinicalLaboratory,Xi’anNo.1Hospital,Shaanxi,Xi’an710002,China.4.KeyLaboratoryforSpaceBioscienceandBiotechnology,SchoolofLifeSciences,NorthwesternPolytechnicalUniversity,Xi'an,Shaanxi,China..*CorrespondencetoTingliLu,e-mail:lutinglixinxin@nwpu.edu.cnFigureS1…………………………………………………………………………S1TableS1……………………………………………………………………….…S2TableS2…………………………….……………………………………………S3

1FigureS1.ReceiveroperatingcharacteristiccurvesshowingtheAUC,sensitivityandspecificityof23differentialmetabolitesfromNOCADandAMIS1

2TableS1.TheoutcomesofAMIpatientswithorwithoutfQRSvariableNon-fQRS(n=58)FQRS(n=60)PvalueAll-causemortality0(0%)8(13.3%)<0.001Cardiacdeath0(0%)6(10.0%)0.013Recurrentangina12(20.7%)27(40.0%)<0.005Re-admissions12(20.7%)30(50.0%)<0.001majoradversecardiovascularevents16(27.6%)35(58.3%)<0.001S2

3TableS2.DifferentialmetabolitesbetweenfQRSandnon-fQRSinAMIgroup.RetentionMass-toFoldMetabolitesVIPPCategorytime(min)chargeratioChangeAcetylglycine*2.300117.05850.792.0990.005AcylglycinesThreoninyl-Glycine*4.697176.06830.731.9910.044GlycinedipeptideGlutarylglycine*2.501189.07400.771.0610.028AcylglycinesNonanoylcarnitine*8.451301.14310.642.0440.030Acylcarnitines*meansthatthemetaboliteswereconfirmedwithreferencecompounds.pvaluesfromMann-Whitney-WilcoxontestandadjustedbyfalsediscoveryratemethodacrossallthemetaboliteswithinthecomparisonS3