molecular chaperones and cell signaling b. henderson, a. pockley (cambridge, 2005) ww外语英文电子书

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1、P1:JZZ0521836549agg.xmlCB856/Henderson0521836549August27,195618:0MolecularChaperonesandCellSignallingThisbookreviewscurrentunderstandingofthebiologicalrolesofextracellularmolecularchaperones.Itprovidesanoverviewofthestructureandfunctionofmolecularchaperones,theirroleinthece

2、llularresponsetostress,andtheirdispo-sitionwithinthecell.Italsoquestionsthebasicparadigmofmolecularchaperonebiology–thattheseproteinsare,firstandforemost,protein-foldingmolecules.Thecurrentparadigmsofproteinsecretionarereviewed,andtheevolvingconceptofproteins(suchasmolecular

3、chaperones)asmulti-functionalmolecules,“moonlight-ingproteins,”isdiscussed.Theroleofexogenousmolecularchaperonesascellregula-torsisexamined,andthephysiologicalandpathophysiologicalrolesthatmolecularchaperonesplayaredescribed.Inthefinalsection,thepotentialtherapeuticuseofmole

4、cularchaperonesisdescribed,andinthefinalchapter,thecrystalballisbroughtoutandthequestion–whatdoesthefutureholdfortheextracellularbiologyofmolecularchaperones–isasked.BrianHendersonisProfessorofCellBiologyattheEastmanDentalInstitute,UniversityCollegeLondon,andHeadoftheCellula

5、rMicrobiologyResearchGroup.Hismajorresearchinterestsareconcernedwithbacterialinteractionswiththehostandhowsuchinteractionscontrolinflammationandassociatedtissuedestruction.Itisthroughthesestudiesthatheidentifiedthatmolecularchaperonesarebacterialvirulencefactorsandstartedhisi

6、nterestinthedirectimmunomodulatoryactionsofcellstressproteins.A.GrahamPockleyisProfessorofImmunobiologyattheUniversityofSheffieldMedicalSchoolandisHeadoftheImmunobiologyResearchUnit.ProfessorPockleyhaslong-standinginterestsintheimmunobiologyoftransplantrejection,andhisunitis

7、currentlyfocussedonresearchrelatingtothebiologyandimmunotherapeuticpotentialofheatshockproteins,particularlytheirinvolvementintherejectionoforgantransplantsandthedevelopmentandprogressionofcardiovasculardisease.iP1:JZZ0521836549agg.xmlCB856/Henderson0521836549August27,19561

8、8:0iiP1:JZZ0521836549agg.xmlCB856/Henderson0521836549August27,195618:0MolecularCha