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1、ADVISORYBOARDDAVIDBALTIMOREROBERTM.CHANOCKPETERC.DOHERTYH.J.GROSSB.D.HARRISONBERNARDMOSSERLINGNORRBYJ.J.SKEHELM.H.V.VANREGENMORTELCONTENTS1.Viruses,Vectors,andVegetation:AnAutobiography1KarlMaramoroschI.FromChildhoodinEuropetoAmerica1II.BrooklynBotanicGarden5III.VirusNo
2、menclatureandClassification13IV.ColdSpringHarbor14V.TheCadang-CadangDisease16VI.DarkCloudsontheHorizon17VII.InsectVirusesandCellCulture17VIII.ElectronMicroscopy21IX.Books22X.InternationalConnections24Acknowledgments26References272.HoneyBeeViruses33YanPingChenandReinholdS
3、iedeI.Introduction34II.CommonHoneyBeeViruses35A.Deformedwingvirus35B.Sacbroodvirus37C.Blackqueencellvirus38D.Kashmirbeevirus39E.Acutebeeparalysisvirus41F.Chronicbeeparalysisvirus42III.Taxonomy43A.Virionproperties43B.Genomeorganizationandclassification45IV.TransmissionMod
4、es49A.Horizontaltransmission50B.Verticaltransmission55C.Discussion56V.Pathogenesis58A.Causalrelationshipbetweenavirusandadisease59B.Tissuetropism59C.Hostrange61vviContentsVI.HostDefenseMechanisms63A.Colony-leveldefense64B.Individual-leveldefense66VII.ManagementofVirusIn
5、fections69VIII.FutureDirections71Acknowledgments72References723.UseofFunctionalGenomicstoUnderstandInfluenza–HostInteractions81JamieL.Fornek,MarcusJ.Korth,andMichaelG.KatzeI.Introduction82II.ModelSystemsofInfluenzaAInfectionUsedinFunctionalGenomics83A.Cellculturemodels83
6、B.Murinemodels86C.Nonhumanprimatemodels90D.Newdiagnosticapproaches93III.Conclusions95Acknowledgments96References964.AGuidetoViralInclusions,MembraneRearrangements,Factories,andViroplasmProducedDuringVirusReplication101ChristopherNetherton,KatyMoffat,ElizabethBrooks,andT
7、homasWilemanI.Introduction103II.Viroplasm,Virosomes,Factories,andInclusions104III.MembraneRearrangementsOccurringDuringtheReplicationofthePositive-StrandedRNAViruses104A.Regulationofmembranetrafficintheearlysecretorypathway106B.Picornavirusreplicationinducesnumerousmembr
8、anevesicles109C.Alphavirusesproducemembraneinvaginationsandspherules117D.TheFlaviviridaereplicateinvesicularpa