课件3-by般若黑洞

《课件3-by般若黑洞》由会员上传分享，免费在线阅读，更多相关内容在教育资源-天天文库。

1、使用须知【般若黑洞】出品。本模板系作者习作，仅限学习交流之用，请勿由于任何商业用途。http://hi.baidu.com/paratop般若黑洞百度一下【般若黑洞】出品NorthwesternPolytechnicUniversity基于大分子的药物控释肿瘤靶向PolymericTumor-TargetingDrugControlledReleaseDrugLoad装载定位TargetingDrugRelease释放胶束Micelles树枝状聚合物DendrimersLiposomes微脂囊聚合物-药物偶联

2、物Polymer-drugconjugatesDrugLoad装载定位主动active被动passiveTargeting配合基-受体Ligand-receptorEPR效应EPREffect叶酸cRGD正常组织癌变部位DrugRelease释放pH温度降解磁场UV电场内因外因PDEAEMAPNIPAM-s-s-hydrazonebonds多层分子设计MolecularDesign嵌段分子量端基ATRPRAFT点击化学超分子星形开环Tumor-TargetingPeptideConjugatedpH-Resp

3、onsiveMicellesasaPotentialDrugCarrierforCancerTherapyXiangLanWu,JongHoKimTumor-Targeting,pH-Responsive,andStableUnimolecularMicellesasDrugNanocarriersforTargetedCancerTherapyXiaoqiangYang,JamisonJ.Grailer,SrikanthPillaPEG-SS-PPS:Reduction-SensitiveDisulfide

4、BlockCopolymerVesiclesforIntracellularDrugDeliveryXiangLanWu,JongHoKimFolate-ConjugatedThermoresponsiveBlockCopolymers:HighlyEfficientConjugationandSolutionSelf-AssemblyPriyadarsiDe,SudershanR.Gondi,andBrentS.SumerlinDevelopmentofmultiple-layerpolymericpart

5、iclesfortargetedandcontrolleddrugdeliveryBhanuprasanthKoppolu,MS,MahamRahim,OSiOSiOSiSiOSiOSiSiOSiOSiOSiOSiHSiOSiOSiHOSiOSiHSiOSiHNH2NHNH2NHNH2NHNNH2graftedPNIPAMShellβ-CDbasedHBPCoreThermo-ResponsiveHyperbranchedpoly(β-CD)s-g-PNIPAMThankyou!PolymericTumor-

6、TargetingDrugControlledReleaseNorthwesternPolytechnicUniversity