免疫细胞的分化发育课件

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1、TheDevelopmentofImmuneCellsFourchaptersTheDevelopmentofImmuneCellsTlymphocyteBlymphocyteBCRandTCRTheoriginofimmunecellsFundamentalImmunology,7theditionThecellsoftheimmunesystemderivefromprecursorsinthebonemarrowQuestion:Areerythrocytesandplateletsimmunecells?Bonemarrow:mostBc

2、ellscompletemostoftheirdevelopment.Bcellsalsooriginateanddevelopinthefetalliverandtheneonatalspleen.Thymus:theprecursorsofmostTcellsmigratefrombonemarrowtothethymus,wheretheydevelopintomatureTcells.SomeTcellsthatformspecializedpopulationswithinthegutepitheliummaymigrateasimma

3、tureprecursorsfromthebonemarrowtodevelopinsitescalled'cryptopatches'justundertheintestinalepithelialcrypts.WewillmainlyfocushereonthedevelopmentofbonemarrowderivedBcellsandthymus-derivedTcells.CentrallymphoidtissuesDevelopmentofBlymphocytesThemainphasesofaBlymphocyte’slifehis

4、toryTheearlystagesofB-celldevelopmentaredependentonbonemarrowstromalcellsStromalcellsformspecificadhesivecontactswiththedevelopinglymphocytesbyinteractionsbetweencell-adhesionmoleculesandtheirligands.Stromalcellssolubleandmembrane-boundcytokinesandchemokinesthatcontrollymphoc

5、ytedifferentiationandproliferationFLT3isrequiredfordifferentiationtothenextstage,thecommonlymphoidprogenitor;IL-7producedbystromalcellsisrequiredforthedevelopmentofB-lineagecells;TheinteractionofVLA-4andVCAM-1promotesthebindingofKitandSCF;B-cellAntigenReceptorBcellantigen-bin

6、dingsiteThedevelopmentalstagesofaB-lineagecellaremarkedbytherearrangementandexpressionoftheimmunoglobulingenesExpressionofsurfaceproteins,receptors,andtranscriptionfactorsinB-celldevelopmentBcellmarkersB-celldevelopmentbeginsbyrearrangementoftheheavy-chainlocusAproductivelyre

7、arrangedimmunoglobulingeneisimmediatelyexpressedasaproteinbythedevelopingBcell.Thepre-B-cellreceptortestsforsuccessfulproductionofacompleteheavychainandsignalsforthetransitionfromthepro-Bcelltopre-Bcellstage.Successfullight-chaingenerearrangementresultsintheproductionofalight

8、chainthatbindstheμchaintoformacompletelgMmolecule,whichisexpressedto