炫酷化学动画PPT-做化学的你值得拥有复习过程.ppt

《炫酷化学动画PPT-做化学的你值得拥有复习过程.ppt》由会员上传分享，免费在线阅读，更多相关内容在教育资源-天天文库。

1、炫酷化学动画PPT-做化学的你值得拥有ETHYLPROPANOATEWhatarethebuildingblocks?ETHYLBENZOATEETHOXIDEIONCARBONHYDROGENsp2orbitalsporbitalsπbondsp3orbitalsαhydrogensOCOOCCCCαhydrogensOCCFORCE&SitesfornucleophilicattacksHighElectronegativityofOxygenResonanceEnergy“Stabilizationenergy”FORCE&FORCE&EthylpropanoateF

2、ormationoftheenolateCondensationwithethylbenzoatetoformβ-ketoesterEt-O-C-CH2–CH3O

3、

4、Lossof2ndalphahydrogenonβ-ketoesterEt-O-C-CH–CH3O

5、

6、-MATHEMATICSEthylPropanoate0.040.140.060.06pKaofalphahydrogens≈24orKa≈10-24MATHEMATICSBondAngles120osp2orbitals109.5osp3orbitals180osporbitals90oporbitalsOv

7、erviewoftheClaisenCondensationReactionEthylPropanoateEthoxideionEthylBenzoate1.Ethoxideionactingasastrongbasedeprotonatesethylpropanoate.2.Theenolateofethylpropanoateisformed.3.Theenolateofethylpropanoateisastrongnucleophilethatattacksthepartiallypositivecarbonofthecarbonylgrouponethylbenzo

8、ate.4.Thealphasubstitutionmakesthisacarbonylcondensationreaction.5.Aβ-ketoesterisformed.+6.Thedrivingforceforthisreactionisthetransferofthesecondalphahydrogentotheethoxideion.Thisisexothermic.DeprotonationofEthylPropanoateResonanceTheenolateionisastrongnucleophileandwillattackthepartiallyp

9、ositivecarbonofacarbonylgroup.+EthylPropanoateEthylBenzoateEnolateofSelfcondensationofethylpropanoateClaisencondensationbetweenEthylBenzoateandEthylPropanoateMechanismoftheRainerLudwigClaisen(1851-1930)Developedthe“ClaisenCondensation”in1887此课件下载可自行编辑修改，仅供参考！感谢您的支持，我们努力做得更好！谢谢