乳腺病理基础---组织学(纪小龙)ppt课件.ppt

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1、乳腺病理要点纪小龙(1)组织学基础Ahistoryofthebreast乳腺＝性器官BreastCancer:FACTSINTHEUSAIncidence200,000/yr.Deaths40,000/yr.Stages:DCIS20%I&II65%III&IV15%2003EstimatedUSCancerDeaths*ONS=Othernervoussystem.*Excludesbasalandsquamouscellskincancersandinsitucarcinomasexcepturin

2、arybladder.Source:AmericanCancerSociety,2003.Men285,900Women270,60025%Lung&bronchus15%Breast11%Colon&rectum6%Pancreas5%Ovary4%Non-Hodgkinlymphoma4%Leukemia3%Uterinecorpus2%Brain/ONS2%Multiplemyeloma23%AllothersitesLung&bronchus31%Prostate10%Colon&rect

3、um10%Pancreas5%Non-Hodgkin4%lymphomaLeukemia4%Esophagus4%Liver/intrahepatic3%bileductUrinarybladder3%Kidney3%Allothersites22%乳腺癌女性恶性肿瘤首位（北京、上海、天津）发病率20-30/10万（美国100+/10万）男性占1%乳腺病理发育异常炎症增生肿瘤良性恶性乳线（1月末、9mm）乳嵴（2月、11.5mm）乳腺始基（3月、仅一对）浅筋膜内2~6肋间150~200克由大汗腺衍生

4、而来多管泡状腺乳腺脂肪体（脂肪囊）胚胎时位于乳线上的皮肤上皮脚下陷皮肤、乳腺、肌肉的关系ducts(D)extralobulerterminalduct(ETD)intralobularpartoftheterminalduct(ITD)ductulesunit(DTL)terminalductlobularunit(TDLU)组织结构要点大导管小叶TDLU15-yrfemale22yrnulli-parous30yrnulli-parous55yrparousinmenopause80yrparous