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1、高向东,男,48岁,博士学位,教授,博士生导师专业方向:微生物学,微生物遗传学,酵母遗传学教育经历:1995/09-1998/06,复旦大学,博士1992/09-1995/07,中国科学技术大学,硕士1987/09-1992/07,中国科学技术大学,学士工作经历:2006/08-至今:武汉大学生命科学学院1999/08-2006/07:美国宾夕法尼亚大学医学院,博士后1998/08-1999/07:美国佛蒙特大学医学院,博士后近五年讲授课程:1.遗传学(全英文教学):生物学国际班和弘毅班本科生必修课,54学时/年2.微生物遗
2、传学:本科生专业选修课,36学时/年3.高级微生物学:研究生专业必修课,54学时/年近五年承担科研项目:1.国家自然科学基金项目:Ras信号传递途径下游效应分子Mhy1与YlRim15在解脂耶氏酵母二型性转换中的功能与调控机制研究(31570076,2016-2019)2.国家自然科学基金项目:酿酒酵母极性生长关键调控分子Rho3的新调控因子、下游效应分子及功能的鉴定(31370124,2014-2017)近五年发表学术论文情况:1.LiangS-H,WuH,WangR-R,WangQ,ShuT,GaoX-D*(2017)T
3、heTORC1-Sch9-Rim15signalingpathwayrepressesyeast-to-hyphatransitioninresponsetoglycerolavailabilityintheoleaginousyeastYarrowialipolytica.Mol.Microbiol.104(4):553-567.2.NieW-C,HeF,YuanS-M,JiaZ-W,WangR-R,GaoX-D*(2017)RolesofanN-terminalcoiled-coil-containingdomainin
4、thelocalizationandfunctionofBem3,aRhoGTPase-activatingproteininbuddingyeast.FungalGenet.Biol.99:40-51.3.YuanS-M,NieW-C,HeF,JiaZ-W,GaoX-D*(2016)Kin2,thebuddingyeastorthologofanimalMARK/PAR-1kinases,localizestothesitesofpolarizedgrowthandmayregulateseptinorganization
5、andthecellwall.PLoSONE11(4):e0153992.4.FeiHe,Wen-ChaoNie,ZongtianTong,Si-MinYuan,TingGong,YuanLiao,ErfeiBi,Xiang-DongGao*(2015)TheGTPase-activatingproteinRga1interactswithRho3GTPaseandmayregulateitsfunctioninpolarizedgrowthinbuddingyeast.PLoSONE10(4):e0123326.5.Hua
6、nWu,JiaGuo,Ya-TingZhou,Xiang-DongGao*(2015)Theanillin-relatedregionofBud4isthemajorfunctionaldeterminantforBud4’sfunctioninseptinorganizationduringbudgrowthandaxialbud-siteselectioninbuddingyeast.Eukaryot.Cell14(3):241-251.6.Yun-QingLi,MinLi,Xiao-FengZhao,Xiang-Don
7、gGao*(2014)ArolefortheRapGTPaseYlRsr1incellularmorphogenesisandtheinvolvementofYlRsr1andtheRasGTPaseYlRas2inbud-siteselectioninthedimorphicyeastYarrowialipolytica.Eukaryot.Cell13(5):580-590.7.MinLi,Yun-QingLi,Xiao-FengZhao,Xiang-DongGao*(2014)RolesofthethreeRasprot
8、einsintheregulationofdimorphictransitionintheyeastYarrowialipolytica.FEMSYeastRes.14(3):451-463.8.YuanLiao,FeiHe,TingGong,ErfeiBi,Xiang-DongGao*(