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1、一26一ZHEJIANGCHEMICALINDUSTRYVo1.45No.7(2014)物,为复杂的羟基肉桂酸衍生物提供一种简便的dase[J].Chem.Pharma.Bul1.,1990,,38(5):1224—1229.中间体制取方法。该工艺在生产过程控制、成本【5】ChenJH,HoCT.Antioxidantactivitiesofcaff~ieacidanditsrelatedhydroxycinnamicacidcompounds[J].J.A—控制及产品质量上,均具有一定市场优势,是一gric.Food.Chem.,1997,45:2374-
2、2378.条适合工业化应用的路线。[6】TouaibiaM,Jean-FranqoisJ,DoironJ.Cafeicacid,a~ersatilepharmacophore:anoverview[J].Mini—Reviewsin参考文献:MedicinalChemistry,2011,ll(8):695-713.【1]GreenawayW,WhatleyFR.Synthesisofestersof~cety-【7】欧仕益.阿魏酸的功能与应用[J].广州食品工业科技,loxycafeicacidsandtheiroccurrenceinpopltrbude
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4、itiesagainstHIV一1integrasestructure-activityrelationship[J].J.Agric.Food.Chem.,andcancercelllines[J].Bioorg.Med.Chem.Lett.,2008,182002,50:468--472.(24):6553-6557.【3】1SahinlerN,Kaftanoglu0.Naturalproductpmpolis:ehemi-[10】YanosukeI,KoichiT,HiroyukiK.Acylcinnamicacidcalcomposition]J].
5、Nat.Prcd.Res.,2005,19(2):183—186.derivatives:JP,,12892[P].1965-07-24.【4】HatanoT,YasuharaT,YoshiharaR,eta1.Effectsofinler-【11】Webster,VictorS.PreparationandoxidationofsubstitutedactioneftannirswithCO-.-existinsubstances—VII.-1nhibito—cinnamicacids[J].Am.J.Pharmacy.,1940.,112:291-296
6、.ryeffectsoftannirsandrela~dpolyphenolsoxanthinecxi—One-potMethodfortheSynthesisofAcety'hydroxycinnamicDerivativesCHENYou—bao’,ZHOU8in-jie,ZHONGGuang-xiang’,XIAChun-nian’(1.CollegeofPharmaceuticalScience,ZhejiangUniversityofTech~logy,Han~hou,Zhejiang310032,Chin~2.Xm#oGreen-HealthPh
7、armaceuticalCo.,Ltd.,Ni~#o,Zhejiang315505,China)Abstract:Thispaperintroducedone-stepdirectsynthesisofacetyhydroxycinnamicderivativesusinghydr0xylbenzaldehydesderivatives.Themethodhasmildreactionconditionandeasytooperate,,theproducthashigh~urity.Theinfluencecfdifferentcatalystandcat
8、alystdosageontheproductwer
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