南药巴戟天质量标准.ppt

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1、ProgressofStudyonTheQualityStandardforMorindaofficinalisHowSchoolofPharmaceuticScienceSunYat-SenUniversityContents1.Nationalstandard1.NationalstandardPropertyIdentificationMicroscopicTLCRefining1.1Propertysurface:dustcolour,yellowandbrowntransversesection:purpleorlilacscylinderwithad

2、iameterabout0.5~2cm,withcrackThosedrugswhicharethick,purpleandnodulararethoughtgood.1.2IdentificationMicroscopicidentification1.2IdentificationMicroscopicidentification1.2IdentificationTLCissimple.feasible,andapplicablefortheidentificationofMorindaofficinalis.Afterbeingpretreatedandco

3、lorreaction,thesameTLCspotsshouldbeseeninthesamepositioncomparedwithreferencedrugs.1.3refiningcrudedrugsdrugsremovedfromwooddrugsprocessedwithsaltpreparedMorindaofficinalisTherewereobviousdifferencesbetweenthecrudeandkindsofdifferentprocessedproductsinthesameconstituentsuchasmonotrope

4、inintheRadixMorindae.2.ProgressProgressImperfectTextLackofevalutaiononthequalityMorindolideRubiadin-1-methyletherChromatographicfingerprintCarbohydrate2.1.Carbohydrate-significancetheconstituentofthehighestrelativecontentinthewholemedicinematerialsanti-stresseffectantidepressanteffect

5、thecytoprotectiveeffectagainstthelesioninducedbycorticosteroneprotectionofapoptosisofosteoblastculturedinvitro2.1.Carbohydrate-methodThemethodofphenol-sulphateacidappliedtodeterminethecontentofpolysaccharidewasprovedtobeprecise,accute,quick,simple,reliableandreproducible.HPCE(highperf

6、ormancecapillaryelectrophoresis)hasbeenusedalotindeterminingoligosaccharidesandmonosaccharideofM.officinalis.BythefingerprintsimilaritycalculationsoftwarewritteninMATLAB(akindofcomputerlanguage),thefingerprintofoligosaccharideshasbeenpreliminaryestablished.2.1.CarbohydrateHoweverItist

7、oohardtoidentifythestructureofthepolysaccharideandtodofurtherrescearchnow.Evencompositionofsomeoligosaccharidesandmonosaccharideisalsotoocomplicatedtodetermine.Therearestillnoestablishedstandards.2.2.Monotropeinakindofiridoidoneofthemaincomponents,whichhasacontentofabout2%contributest

8、othea