法国赛比克-微胶囊包裹技术.pdf

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1、Microencapsulation&DeliverysystemsAnewactivityatSEPPICJanuary20104470/GB/January2010Introduction:DefinitionsMicroencapsulationActiveIsolationofanactiveingredientfromtheingredientexternalenvironment(protectionoftheactivematerialoroftheworkers)thankstoaliquidorasolidbarrier.Con

2、trolledreleaseReleaseoftheactiveingredientthankstoatriggerattherightplace,andattherightmoment,accordingtoadesiredkinetics“activeingredient”doesn’tmean“pharmaceuticalactivemolecule”4470/GB/January20102DifferenttypesofcapsulesActiveingredientMembranesMembraneActiveingredientMatri

3、cesMatrixActiveingredientInclusionsorspongesSolidporoussupport4470/GB/January20103Microcapsules:MainmanufacturingprocessesSolidmembranes-Filmcoating,interfacialpolymerization,hotmeltcoating-CoacervationLiquidmembranes-Liposomes,emulsionsMatrices-Prilling;drippingSEPPIC’s-Sol

4、ventevaporationKnowhow-Compression-Polymerprecipitation-Granulation(wetorspraydrying)-Soliddispersion(SLN)-ExtrusionInclusions-Absorptionin(oron)solidporoussupports-Resinates-Complexationincyclodextrines4470/GB/January20104ChoiceofanencapsulationtechnologyThereisnouniversaltec

5、hnologyActiveingredientThebestchoicedependson:ThetypeandthesizeofdesiredmicrocapsuleThecharacteristicsoftheactiveingredientThetypeoftriggerThedesiredkineticsofreleaseThemediumwheretheactiveingredientmustbereleasedTheacceptablecost4470/GB/January20105Encapsulationprocesses

6、choices:guidelinesPropertiesofthedesiredmicrocapsulesPropertiesoftheSolid,withasizeofaboutLiquid,withasizeofaboutactiveingredient<100µm100–5000µm>5000µm0.01-0.1µm0.1-100µmCoacervation+emulsionE/HAtomisationCompressionEmulsification(W/O)GranulationGranulationMicroEmulsificationS

7、olidhydrophilicCoating(W/O)ResinatesIfØ>100µm*GelinOilCoatingIfØ>5000µm*AbsorptionIfØ<10µm*GranulationAtomisationCompressionEmulsificationCoacervationGranulationMicroEmulsification(solidlipidicmatrices)SolidhydrophobicAbsorption(O/W))Emulsification(O/W)IfØ<10µm*CoatingCoacervat

8、ionIfØ>5000µmCoatingIfØ>100µm*Coacervation+emulsionE/H