血液病英文ppt讲解学习.ppt

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1、TheDiseasesofHematopoieticandlymphoidsystemsStructureandfunctionHematopoieticandlymphoidsystemiscomposedofmyeloidtissue(bonemarrow)andlymphoidtissues(thymus,spleen,lymphnodesandextranodelymphoidtissues).ThethymusandbonemarrowareoftentermedcentrallymphoidtissuesTherema

2、iningorgansareactivelyinvolvedintheimmuneresponse,andconstitutetheperipherallymphoidtissue.DiseasesInfectionandreactiveproliferationsThelymphoidneoplasmasMyeloidneoplasmsHistocyticneoplasmsLymphoidneoplasmsAlllymphoidneoplasmsarederivedfromasingletransformedcellandare

3、thereforemonoclonal.Lymphoidneoplasmsareagroupoftumorsthattheirclinicalmanifestationsandbehaviorvarywidely.Theyareclassifiedasnon-Hodgkin’slymphoma(NHLs)andHodgkins’slymphomabasedonthefeaturesoftumorcells.NHLsaccountforabout70%to80&ofallmalignantlymphomasinourcountry.

4、ClassificationoflymphoidneoplasmsTheaimofclassificationistoidentifyhomogeneroussubgroupsthatbehaveinapredictableway.Thelymphoidneoplasmsarenamedaccordingtothenormalcelltheymostcloselyresemble.WHOclassifications(2000)intable9-1(page276).1948Willis:“Nowhereinpathologyha

5、sthechaosofnamessocloudedclearconceptsasinthesubjectoflymphoidtumors”分类：NHL分类方法多，分型繁杂ClassificationThreemajorcategories:1TumorsofB-cells2TumorsofT-cellsandNK-cells3Hodgkin’slymphomaNon-Hodgkin’slymphomaEtiology(1)1.virusMurine、feline、avianleukemiasretrovirusesadultTce

6、lllymphoma-leukemiaHTLV-1Burkitt’slymphomaEBVEtiology(2)2.oncogenesBurkitt’slymphoma:t(8;14)myc-Igfollicularlymphoma:t(14;18)bcl-2-IgCLL:Philadelphiachromosomet(9,22)c-abl,bcrEtiology(3)3.Autoimmune&immunodeficienyDiseaseeg.Receptoroftransplantedorgans.AIDSpatientslym

7、phomaLeukemia/LymphomaThesearehigh-gradeNHLscomposedofdiffusesheetsofmedium-sizelymphoidcells.TheymaybeB-orT-celllineage.Theseaggressivetumorsaffectpredominantlyinchildren,accountingfor80%ofchildhoodleukemia.Thepre-B-celllymphomamainlyaffectschildren,butthePre-T-cellt

8、umorsmainlyaffectadolescentmales.MorphologyMircoscopically,thelymphnodesaffectedbyneoplasticcellsarereplacedbysmalltomedium-