资源描述：
《生物医用高分子材料课件.ppt》由会员上传分享，免费在线阅读，更多相关内容在教育资源-天天文库。
1、生物医用高分子材料------制备及性能研究主要研究方向1)水凝胶生物医用材料的研究；2)水凝胶药物控制释放系统、可注射型凝胶的研究；3）智能水凝胶（温度、pH敏感性水凝胶）及其“开-关”药物控制释放系统研究；3)高分子材料的表面改性研究。什么是水凝胶?一种高分子材料具有亲水性具有三维网络结构在水中可溶胀但不溶解ApplicationControlleddeliverysystemsMedicaldevicesWounddressingScaffoldsintissueengineering……SoftContactLensPHEMAApplicationofradiat
2、ionpolymerizationTheskindonorwoundishealingafter12daysofcoveringwithPVAhydrogelwounddressing*Speedshealing*Painlessremoval*Transparency*NoresiduePVAHYDROGELWOUNDDRESSINGMagnetictargeteddrugreleasinghydrogelmicrospheresMacromol.Symp.,2005,225:95-102SurfacemodificationContraceptiveringforth
3、emodificationofantibacterialanddrugreleasepropertiesGraftingmodificationofPP,PE,siliconrubsurfaceforhydrophilicandantibacterialfilmsandtubesRadiat.Phys.Chem.,1998,52(1-6):201-206Radiat.Phys.Chem.1999,55:87-92Radiat.Phys.Chem.2000,59:313-316X-rayirradiationDose:2GyHydrogel3Ddosimeterforthe
4、determinationofdosedistributioninradiotherapyoftumorsHydrogeldosimeterbasedoncolorchangewithdifferentirradiationdoseDose(Gy)0.511.523456EBX-rayNuclearScienceandTechniques,2009,6:152-156Environmentalsensitivehydrogels temperatureandpHsensitiveH2OH2OH2OH2OH2OstimulationsH2OH2OH2OH2O生物医用高分子材
5、料------制备方法RadiationPolymerizationMR●(Formoffreeradical)R●RM●PolymerR●+O2ROO●ROOH+R●ROO●+R●(orROO●)ROOR(or+O2)ROOR(orROOH)RO●(or●OH)+M+nM∆+MRADIATIONCROSSLINKINGlinearpolymerPolymericnetworkCH2CHCH22CH2CHCH2CH2CHCH2HCH2CH2CH2CH2CHCH2H2CH2CH2CH2CH2CHCH2HChapiroA.,RadiationChemistryofPolyme
6、ricSystem,1962,byJohnWileyandSons,Inc.pp354RadiationgraftcopolymerizationSimultaneousradiationgraftingofmonomerwithradiation-inducedpolymerradicalsChapiroA.,RadiationChemistryofPolymericSystem,1962,byJohnWileyandSons,Inc.pp600Advantagesofradiation–inducedpolymerizations1.Noinitiators(orcr
7、osslinkingagents)areneeded.Purepolymercanbeobtained.2.Reactionscanbeperformedinanyphysicalstateofthemonomer(e.g.ingas,liquidsolutionorsolidstate).3.Reactionmaybeperformedatroomtemperature,andevenatverylowertemperature(e.g.atliquidnitrogentemperatureinsolidstate).4.D
