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1、壳聚糖论文：壳聚糖的改性研究【中文摘要】本论文首先利用甲氧基聚乙二醇(mPEG)改善壳聚糖的水溶性。将不同分子量的mPEG的羟基羧化后,与壳聚糖分子链上3位羟基发生酯化反应,制备出梳形可分散于水的甲氧基聚乙二醇接枝壳聚糖(CS-g-mPEG)。采用红外光谱(IR)、核磁共振(1H-NMR)对CS-g-mPEG的结构进行了表征,结果表明这种方法可以成功制备CS-g-mPEG。接枝共聚物水溶性实验表明,CS-g-mPEG接枝共聚物的溶解性得到显著提高。为了改善壳聚糖的脂溶性,本论文在壳聚糖上面引入聚乳酸,壳聚糖上的羟基引发丙交酯开环聚合
2、得到壳聚糖-聚乳酸(CS-g-PLA)接枝共聚物。采用红外光谱(IR)和核磁共振(1H-NMR)表征了接枝共聚物的结构。共聚物的脂溶性实验表明,壳聚糖接枝聚乳酸后可以溶解在部分有机溶剂中。另外,本文还利用胺解技术在聚乳酸膜表面引入自由氨基,再利用戊二醛将氨基转化为自由醛基,然后用壳聚糖涂层的方法,制备了壳聚糖表面改性的聚乳酸膜载体。采用红外光谱(IR)对改性聚乳酸膜的结构进行分析表征。结果表明,壳聚糖可以成功固定在聚乳酸膜表面。壳聚糖接枝聚乳酸膜表面后可以改善聚乳酸的生物相容性。【英文摘要】Firstly,watersolubili
3、tyofthechitosanwasimprovedbymethoxypoly(ethyleneglycol)(mPEG)inthispaper.mPEGwithdifferentmolecularweightsaftercarboxylatedwasoccurredesterificationreactiontothehydroxylgroupsatC-3onthechitosanbackbone,andthecomb-shapedmethoxypoly(ethyleneglycol)graftedchitosan(CS-g-mP
4、EG)whichcanbedispersedinwaterwasprepared.ThestructureofCS-g-mPEGwascharacterizedbyinfraredspectroscopy(IR)andnuclearmagneticresonance(’H-NMR),andtheresultsshowedthatCS-g-mPEGcanbesuccessfullypreparedbythismethod.Water-solubleexperimentofthegraftcopolymershowedthattheso
5、lubilityoftheCS-g-mPEGgraftcopolymerwasimprovedsignificantly.polylactide(PLA)wasintroducedtochitosan,andthegraftcopolymerofchitosan-g-polylactide(CS-g-PLA)wassynthesizedsuccessfullythroughringopeningpolymerizationbythehydroxylgroupofthechitosaninitiated,inordertoimprov
6、efatsolubility.ThestructureofthisgraftcopolymerwascharacterizedbyIRand1H-NMR.Fat-solubleexperimentofthecopolymershowedthatchitosangraftedPLAcandissolveinpartialorganicsolvents.Inaddition,inthispaper,thefreeaminowasintroducdtothesurfaceofthePLAmembranebyusingaminolysist
7、echnique,andaminogroupwastransformedintoadehydegroupbyusingglutaraldehyde,thenchitosan-modifiedPLAmembranewasfabricatedbychitosan-coatingtechnique.ThestructureofthemodifiedPLAwascharacterizedbyIR.Theresultsshowedthatchitosancanbesuccessfullyfixedinthesurfaceofthepolyla
8、ctidemembrane.ThebiocompatibilityofPLAcanbeimprovedafterchitosangraftedthesurfaceofPLAmembrane.【关键词】壳聚糖接枝共聚物甲氧基聚乙二醇聚乳
