本科艾滋病英文版.ppt

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1、AIDSDepartmentofInfectiousDiseases，TheYongchuanHospitalofChongqingmedicalUniversityliweiSummaryAIDS=AcquiredImmuno-DeficiencySyndromeHIV=HumanImmunodeficiencyVirusAIDS,whichfeaturesaprogressivedepletionofCD4+Tlymphocytes,leadingtolife-threateningopportunisticinfections,wasfirstrecognizedi

2、n1981intheunitedstates。HIV病毒模式图EtiologythestructureofHIV包膜蛋白跨膜蛋白逆转录酶核心蛋白蛋白酶外膜P17蛋白EpidemiologyAsof2012,approximately35.3 millionpeoplearelivingwithHIVglobally.thedomesticsituationasof2012,morethan380,000peoplearelivingwithHIV.sourceofinfectionPatientswithHIVAsymptomaticHIVcarriersHIVinblo

3、od、semen、vaginalfluid、breastmilk。HIVinBodyFluidsSemen11,000Vaginalfluid7,000Blood18,000Amnioticfluid4,000Saliva1TherearedifferentamountsofHIVinvariousbodilyfluidsRouteoftransmissionSexualcontact（thepredominantmode）homosexheterosexBloodtobloodcontactVerticaltransmissionothers同之恋毒之祸血之灾susce

4、ptiblepopulationMostofpeoplearesusceptibletoHIVThechangehasmadethevirusspreadingfromdrugusersandsexworkerstogeneralpopulation.pathogenesisHIVcaninfectthosecellsthatexpressCD4onthesurface.DuringthecycleofHIVlife,CD4+TcellshavebeendirectlyandindirectlydamagedHIVLIFECYCLEHIV生长周期HIVcandamaget

5、hosecellsthatexpressCD4onthesurfaceCD4+TcellsCD8+TcellsBcellsLangerhanscellsmonocytes/macrophagesfolliculardendriticcellsClinicalManifestationsPeriodoflatentinfection：2～10yearsⅠstage:primaryinfectionⅡstage:asymptomaticinfectionⅢstage:AIDS010020030040050060070080090010000123451234567891011

6、CD4+cellCountAsymptomaticHZVOHLOCPPEPCPCMCMV,MACTBMonthsYearsAfterHIVInfectionCommonNaturalCourseofHIVInfectionComplicationsAcuteHIVinfectionsyndromeRelativelevelofPlasmaHIV-RNACD4+TcellsManifestationsatlastperiodAIDS-relatedsyndromeRespiratorymanifestationsNeurologicalandocularmanifestat

7、ionsGastrointestinalmanifestationsOthersystematicmanifestationsRespiratorymanifestationsRecurrentrespiratorytractinfectionsPneumocystispneumoniaTuberculosisMACfungusNeurologicalandocularmanifestationscryptococcalmeningitistubercularmeningitistoxoplasmicencephalitisH