生物化学英文版习题.doc

《生物化学英文版习题.doc》由会员上传分享，免费在线阅读，更多相关内容在工程资料-天天文库。

1、I.FuelMetabolismPART1:StructureandFunctionofProteinDirections:Eachofthenumbereditemsorincompletestatementsinthissectionisfollowedbyanswersorbycompletionsofthestatement.Selecttheoneletteredanswerorcompletionthatisbestineachcase.Questions9and10Usethestructuretoanswerquestions9and10

2、：Asp-Ala-Ser-Glu-Val-Arg9.TheC-terminalaminoacidofthehexapeptideshownis(A)alanine(B)asparagine(C)aspartate(D)arginine10.AtphysiologicpH(7.4),thishexapeptidewillcontainanetchargeof(A)-2(B)-1(C)0(D)+1(E)+211.Whichoneofthefollowingtypesofbondsiscovalent?(A)Hydrophobic(B)Hydrogen(C)D

3、isulfide(D)Electrostatic13.Whichoneofthefollowingconditionscauseshemoglobintoreleaseoxygenmorereadily?(A)Metabolicalkalosis(B)Increasedproductionof2,3-bisphosphoglycerate(BPG)(C)Hyperventilation,leadingtodecreasedlevelsofCO2intheblood(D)Replacementoftheβsubunitswithγsubunits14.P

4、roductionofwhichofthefollowingproreinswouldbemostdirectlyaffectedinscurvy?(A)Myoglobin(B)Collagen(C)Insulin(D)Hemoglobin15.Theactivesiteofanenzyme(A)isformedonlyafteradditionofaspecificsubstrate(B)isdirectlyinvolvedinbindingofallostericinhibitors(C)residesinafewadjacentaminoacidre

5、siduesintheprimarysequenceofthepolypeptidechain(D)bindscompetitiveinhibitors16.AnenzymecatalyzingthereactionE+S=ES→E+Pwasmixedwith4mMsubstrate.Theinitialrateofproductformationwas25%ofVm.TheKmfortheenzymeis(A)2mM(B)4mM(C)9mM(D)12mM(E)25mM17.Thevelocity(v)ofanenzyme-catalyzedreact

6、ion(A)decreasesasthesubstrateconcentrationincreases(B)islowestwhentheenzymeissaturatedwithsubstrate(C)isrelatedtothesubstrateconcentrationatlhVm(D)isindependentofthepHofthesolutionQuestions18and19Refertothefollowingreactionwhenansweringquestions18and19.Fumarate+H20↔malatefumaras

7、e18.Fumarasecatalyzestheconversionoffumaratetomalate.IthasaKmof5μMforfumarateandaVmaxof50μmol/min/mgofproteinwhenmeasuredinthedirectionofmalateformation.Theconcentrationoffumaraterequiredtogiveavelocityof25μmol/min/mgproteinis(A)2μM(B)5μM(C)10μM(D)20μM(E)50μM19.TheKmforfumaraseisa

8、pproximately5μMforfumarate