遗传学这次良心了.doc

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1、截止10.281.Multiplestudiesofagivendisorderamongsiblingshaveestimatedtheheritabilityofthedisorderasequalto0.85.Whatdoesthisfindingrevealaboutthecauseofthisdisorder?(12.0分)A.Thisdisorderislikelycausedbyasinglegene,withnoenvironmentalinfluencesB.Themajorityofthevarianceinthephenotypeofthisdisea

2、seiscausedbygeneticinfluencesC.Environmentalfactorsexertagreaterinfluenceoverdiseaselikelihhoodthangeneticfactors2.Tosaythattwoallelesareinlinkagedisequilibriumimpliesthat:(12.0分)A.Theallelesaresoclosethatrecombinationneveroccursbetweenthem.B.Theallelesfunctiontogetherinthesamepathway.C.On

3、eallelearosefromtheotherbymutation.D.Thetwoallelesaretogetherinthesamehaplotypemoreoftenthatpredictedbychance.3.AssociationStudies:(12.0分)A.CangivefalsepositiveresultsduetopopulationstratificationB.Includethetransmissiondisequilibriumtest(TDT)C.AreusedtomapgenesinmultifactorialdisordersD.P

4、ositiveassociationstudiesshouldbereplicatedE.Requirecloselymatchedcontrolandpatientgroups4.Whichofthefollowingstatementsisincorrectregardingtherecurrenceriskofmultifactorialinheriteddisorders.(12.0分)A.TheriskfortheirchildrengetshigherwhenthepatientsareseriouslyaffectedB.Theriskgetshigherwh

5、enthedegreeofrelationshipincreasesC.TheriskgetshigherwhenthenumberofpatientsinthefamilyincreaseD.Theriskgetshigherwhenoneorbothparentsareaffected.5.Whenisthefemalegenitalductdevelopmentcompleted?(14.0分)A.At10-11weeksofgestationB.At7weeksC.At18-20weeksofgestationD.At9-10weeksofgestationE.Be

6、tween8and20weeksofgestation6.Amultifactorialtraitoccursmoreofteninfemalesthanmales.Acouplehaveanaffectedson.Whichofthefollowingistrueregardingtheirriskofrecurrence?(12.0分)A.Recurrenceishigherthaniftheyhadanaffecteddaughter,andismostlikelyforafuturedaughter.B.Recurrenceishigherthaniftheyhad

7、anaffecteddaughter,andismostlikelyforafutureson.C.Recurrenceishigherthaniftheyhadanaffecteddaughter,andismostlikelyforafuturedaughter.D.Recurrenceislowerthaniftheyhadanaffecteddaughter,andismostlikelyforafuturedaughter.7.Linkageanalysisismoredifficultinmultifa