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时间:2020-05-14
《淋巴细胞亚群和调节性T细胞在多发性骨髓瘤患者外周血的表达分析及与预后的关系.pdf》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、中国实验诊断学2015年7月第19卷第7期文章编号:1007—4287(2015)07—1III一04淋巴细胞亚群和调节性T细胞在多发性骨髓瘤患者外周血的表达分析及与预后的关系高鹏,王雪野,肖中平,付垄,孔令环,王雪梅,李凌君,封韬,韩梅(吉林省人民医院血液科,吉林长春130021)摘要:目的通过检测多发性骨髓瘤(MM)患者外周血T、B淋巴细胞及调节性T细胞(Tregs)水平,评估MM患者免疫功能状态及与预后的关系。方法测定3O例MM患者和2O例健康志愿者外周血T、B淋巴细胞及Tregs的百分比,分析MM患者血清口2一微球蛋白(p2一MG)、白蛋白(ALB)、血肌酐(CRE)、血红蛋白(HGB
2、)水平与Tregs的相关性。结果(1)与对照组比较,MM组患者外周血CD3、CD4比例无统计学意义;NK细胞的比例增高,CD4CD25hishCD127/一T细胞/CD4T细胞(Tregs)增高,CDI9细胞的比例下降,CD8细胞的比例升高,CD4/CD8比值下降,差异有统计学意义(P3、;T淋巴细胞亚群;调节性T细胞中图分类号:R733.3文献标识码:AAnalysisofTLymphocyteSubsetsandTregsinPeripheralBloodofPatientswithMultipleMyelomaanditsCorrelationwithPrognosticFactorsGAOPeng,WANGXue—ye,XIAOZhong—ping,eta1.(DepartmentofHematology,Jilin.Pr0一incePeoplesHospital,Changchun130021,China)Abstract:0bjectiveToevaluateimm4、unestateandanalyzeitsprognosticfunctionofpatientswithMMbydetectthechangesoftheTlymphocytesubsets,BcellsandTregsinperipheralbloodofpatientswithMM.MethodsThepercentageofTlymphocytesubsets,BcellsandTregcellsinperipheralbloodof30patientswithMMand20healthydonorswasmeasured.TheassociationofTregsoftheMMpat5、ientswithB2一MG,serumalbumin,serumcreatinine,he—moglobinwereanalyzed.ResultsComparedwiththecontrolgroup,thepercentageofCDl9,CD4/CD8werereducedandthepercentageoftheCD8。NK,CD4CD25“ghCD127。一Tcells/CD4+Tcells(Tregs)waselevatedinpatientswithMM(P<0.05).TheTregcellshadpositivecorrelationwiththelevelofB2一MGa6、ndhadnegativecorrelationwiththelevelofserumalbumin,hemoglobin,serumcreatinine.ConclusionMMPatientshaveadisorderoflymphocytesub—setsandhaveanabnormalamplificationofCD4CD25ghCD127。Tregcells.whichmaybeanimportantmechanismofMMimmunedeficiencyandimmuneescape.Ithadcertainreferencevalueinjudgingtheprognosi7、softhepatientswithMM.Keywords:multiplemyeloma;Tlymphocytesubsets;Tregs(ChinJLabDiagn,2015,19:1111)多发性骨髓瘤(Multiplemyeloma,MM)是常作用n]。本研究采用流式细胞术检测30例MM患见于老年人的血液系统恶性肿瘤,疾病进展较慢,浆者及2O例健康志愿者外周血淋巴细胞亚群、Tregs细胞异
3、;T淋巴细胞亚群;调节性T细胞中图分类号:R733.3文献标识码:AAnalysisofTLymphocyteSubsetsandTregsinPeripheralBloodofPatientswithMultipleMyelomaanditsCorrelationwithPrognosticFactorsGAOPeng,WANGXue—ye,XIAOZhong—ping,eta1.(DepartmentofHematology,Jilin.Pr0一incePeoplesHospital,Changchun130021,China)Abstract:0bjectiveToevaluateimm
4、unestateandanalyzeitsprognosticfunctionofpatientswithMMbydetectthechangesoftheTlymphocytesubsets,BcellsandTregsinperipheralbloodofpatientswithMM.MethodsThepercentageofTlymphocytesubsets,BcellsandTregcellsinperipheralbloodof30patientswithMMand20healthydonorswasmeasured.TheassociationofTregsoftheMMpat
5、ientswithB2一MG,serumalbumin,serumcreatinine,he—moglobinwereanalyzed.ResultsComparedwiththecontrolgroup,thepercentageofCDl9,CD4/CD8werereducedandthepercentageoftheCD8。NK,CD4CD25“ghCD127。一Tcells/CD4+Tcells(Tregs)waselevatedinpatientswithMM(P<0.05).TheTregcellshadpositivecorrelationwiththelevelofB2一MGa
6、ndhadnegativecorrelationwiththelevelofserumalbumin,hemoglobin,serumcreatinine.ConclusionMMPatientshaveadisorderoflymphocytesub—setsandhaveanabnormalamplificationofCD4CD25ghCD127。Tregcells.whichmaybeanimportantmechanismofMMimmunedeficiencyandimmuneescape.Ithadcertainreferencevalueinjudgingtheprognosi
7、softhepatientswithMM.Keywords:multiplemyeloma;Tlymphocytesubsets;Tregs(ChinJLabDiagn,2015,19:1111)多发性骨髓瘤(Multiplemyeloma,MM)是常作用n]。本研究采用流式细胞术检测30例MM患见于老年人的血液系统恶性肿瘤,疾病进展较慢,浆者及2O例健康志愿者外周血淋巴细胞亚群、Tregs细胞异
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