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时间:2020-05-14
《肝细胞肝癌血清AFP值与HBV感染的关系.pdf》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、徐建波,等肝细胞肝癌血清AFP值与HBV感染的关系消化·泌尿系肿瘤专肝细胞肝癌血清AFP值与HBV感染的关系徐建波,祁付珍,魏天翼,时汀,许刚,张建淮RelationshipbetweenserumAFPIevelandHBVii1patientswithhepatocellularcarcinomaXuJianbo,QiFuzhen,WeiTianyi,ShiTin,XuGang,ZhangJianhuaiDepartmentofGeneralSurgery,Huai~mFirstPeople'sHospital,NanfingMedicalUniversity,JiangsuHua
2、i'an223300,China.【AbstractlObjective:ToinvestigatetherelationshipbetweenserumAFPlevelandHBVofHCCpatients.Meth·ods:Aretrospectivestudywasconductedonpatientswhowerediagnosedwithlivermalignantneoplasmandreceived.surgerytreatmentfromJanuary,2009toJune,2011.Results:Atotalof217patientswithlivermaligna
3、ntneoplasmwereenrolledinthisstudyincluding176hepatocellularcarcinoma(HCC)patientsand41otherlivertumorpatients.InHCCpatientswithHBVinfection,thefirstthreeofHBV—infectionmodelbeingHBsAg,HBeAbandHBcAbposi—tive(secondarythreepositive),HBsAgandHBcAbpositiveandHBsAg,HBeAgandHBcAb(mainthreepositive)wit
4、h30.7%.25.6%and20.5%respectively.HCCpatientsshowedasignificantlyhigherserumAFPlevelsthanoth—erlivetumorpatients(P<0.001).However,inHCCgroup,HBVinfectiondidnotaffecttheprobabilityofshowinganelevatedAFP(P:0.147),andtherewasnosignificantdifferenceamongpatientswithsecondarythreepositive,HBsAgandHBcA
5、bpositiveandmainthreepositive(P=0.578).Similarly,thetopthreeHBV—infectionmodelsdidnotaffectthelevelsofseI'umAFPregardlessofAFPnegativeorAFPpositive.Conclusion:HCCpatientshaveasig—nificantlyhigherserumAFPlevelsthanotherlivetumorpatients,butthereisnosignificantrelationbetweenAFPlev·elsandHBV—infec
6、tionmodels.【Keywords】hepatocellularcarcinoma;hepatitisvirusB;alpha—fetoprotein(AFP)ModeruOncology2014,22(12):2900—2902【摘要】目的:探索肝细胞肝癌患者血清AFP值与HBV感染模式的关系。方法:回顾性分析2009年1月到2011年6月于我院就诊并手术的所有肝脏恶性肿瘤患者的临床资料。结果:共有217例肝脏恶性肿瘤患者纳入研究:肝细胞肝癌(HCC)组176例,非HCC组41例。HCC组中HBV感染模式前三位的分别是HBsAg,HBeAb和HBcAb阳性(小三阳)(30.7%
7、),HBsAg和HBcAb阳性(25.6%)及HBsAg,HBeAg和HBcAb阳性(大三阳)(20.5%)。HCC组血清AFP值高于非HCC组血清AFP值(P<0.001),但HCC组内HBV感染组与非HBV感染组之间血清AFP水平无统计学差异(P=0.147),三种主要HBV感染模式之间血清AFP值也无统计学差异(P=0.578)。同样的,无论在AFP阴性组(<20ng/m1)还是AFP阳性组(~>20ng/m1),三种主要的HBV感染模式
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