单唾液酸四己糖神经节苷脂钠联合脑蛋白水解物治疗帕金森病的疗效观察-论文.pdf

《单唾液酸四己糖神经节苷脂钠联合脑蛋白水解物治疗帕金森病的疗效观察-论文.pdf》由会员上传分享，免费在线阅读，更多相关内容在应用文档-天天文库。

1、·药物与临床·十一I药斜誓2014年9月第4卷第17期单唾液酸四己糖神经节苷脂钠联合脑蛋白水解物治疗帕金森病的疗效观察尹忠平邓雷梅罗昌菊文晓菲贵州省黔东南州人民医院内科，贵州凯里556000【摘要】目的探讨单唾液酸四己糖神经节苷脂钠联合脑蛋白水解物治疗帕金森病的疗效。方法按照随机数字表法将86例帕金森病患者均分为实验组和对照组，对照组患者单用单唾液酸四己糖神经节苷脂钠注射液治疗，实验组患者采取单唾液酸四己糖神经节苷脂钠注射液联合注射用脑蛋白水解物治疗，比较两组患者治疗效果。结果两组患者治疗后UPDRS总评分均显著下降，与治疗前比较，差异具有统计学意义(P<0．

2、05)；实验组患者UPDRS总评分显著低于对照组，总有效率显著高于对照组，差异具有统计学意义(P<0．05)；两组患者不良反应发生率比较，差异无统计学意义(尸>0．05)。结论单唾液酸四己糖神经节苷脂钠联合脑蛋白水解物能够显著改善帕金森病患者UPDRS评分，临床疗效显著。【关键词】单唾液酸四己糖神经节苷脂钠；脑蛋白水解物；帕金森病【中图分类号】R971．5【文献标识码】B【文章编号】2095—0616(2014)17—48一O3Observationontheefficacyofmonosialotetrahexosylgangliosidesodiuminj

3、ectioncombinedwithbrainproteinhydrolysateforthetreatmentofParkinsondiseaseY／NZhongpingDENGLeimeiLUOChangjuWENXiaofeiDepartmentofInternalMedicine，NanzhouPeople’SHospitalofQiandong，Kaili556000，China[Abstract]ObjectiveToexploretheefficacyofm0nosia1otetrahexosylgangliosidesodiuminjectio

4、ncombinedwithbrainproteinhydrolysateforthetreatmentofparkinsondisease．Methods86casesofpatientswithparkinsondiseasewererandomlydividedintoexperimentgroupandcontrolgroup．Thecontrolgroupweretreatedbymonosialotetrahexosylgangliosidesodiuminjection，theexperimentgroupweretreatedbym0nosial

5、otetrahexosy1gangli0sidesodiuminjectioncombinedwithbrainproteinhydrolysate．Theclinicalefectswerecomparedforthetwogroups．ResultsThescoresofUPDRSposttreatmentforthetwogroupswerelowerthanpriortreatment(P<0．051：ThescoresofUPDRSposttreatmentfortheexperimentgroupwerelowerthanthecontrolgro

6、up(P<0．05)；Thetotalefectiverateoftheexperimentwashigherthanthecontrolgroup(P<0．05)；Therewasnosignificantdifferenceontherateofadversereaction(P>0．05)．ConclusionTheeficacyofmonosialotetrahexosylgangliosidesodiuminjectioncombinedwithbrainproteinhydrolysateforthetreatmentofparkinsondise

7、aseisgood，itcanimprovethescoresofUPDRS．Theclinicalcurativeefectisdistinct．[Keywords]Mon0sial0tetrahexosylgangliosidesodiuminjection；Brainproteinhydrolysate；Parkinsondisease帕金森病是常见中枢神经系统变性疾病，患者常规检查确诊，排除合并严重脏器功能不全者、存以运动障碍、认知功能障碍等为主要临床特点，多在精神系统疾病者、继发性帕金森病综合征以及帕发于老年人群[11。临床研究表明，单唾液酸四己糖金

8、森病叠加综合征患者。按照随机数字表法将