单纯多滤泡卵巢妇女的糖代谢水平的变化

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1、第28卷第2期西安交通大学学报(医学版)Vol.28No.22007年4月JournalofXi，anjiaotongUniversity(Medicalsciences)APr.2007单纯多滤泡卵巢妇女的糖代谢水平的变化吕淑兰，郭小燕，曹绩孙，毛文军(西安交通大学医学院第一附属医院妇产科，陕西西安710O61)摘要:目的研究单纯多滤泡卵巢(MOF)妇女的糖代谢水平，探讨其与胰岛素抵抗及体重的关系。方法46例MOF妇女及30例正常对照女性，口服759葡萄糖，行糖耐量试验(OGTT)及同步胰岛素释放试验(IRT)，用稳态模

2、型胰岛素抵抗指数(HOMAIR)测评胰岛素抵抗。结果①MOF糖耐量低减的发生率为10.87%，明显高于对照组3.3%(尸<0.05)。胰岛素抵抗的发生率为30.43%，对照组为10.0%，两组比较差异有统计学意义(尸<0.05)。②两组的性激素水平，即FSH、LH、PRL、E:、T和P的差异无统计学意义(P>。.o5)。③糖耐量低减妇女BMI与胰岛素抵抗呈正相关(r=0.567，尸<0.05)。结击单纯多滤泡卵巢妇女存在一定程度的糖代谢异常;肥胖和胰岛素抵抗是导致糖耐量异常的主要原因。MOF肥胖妇女应行OGTT监测糖代谢状

3、况。关键词:多滤泡卵巢;糖代谢;胰岛素抵抗;糖耐量低减中图分类号:R711，59文献标识码:A文章编号:1671一8259(2007)02一0181一03EvaluationoftheglucosemetabolisminwomenwithunitarymultiPleOVarlanfolliCleSL位Shulan，GuoXiaoyan，CaoZuansun，MaoWe川11(DepartmentofObstetricsandGynecology，theFirstAffiliatedHospital，Medicalsch

4、oolofXi’anjiaotongUniversity，Xi’an7lO061，China)ABSTRACT:Ob】ectiveToinvestigatetheglucosemetabolismconditionofwomenwithunitarymultipleovarianfollicles(MOF)andtoexPloretherelationshiPamongtheglucosemetabolism，insulinresistanceandbodyweightMethodsAtota1of46womenwithm

5、u1tiPlefollicularovaryand3onormalwomenwerestudied.Allofthesewomentook75gofglucoseorallyfortheoralglucosetolerancetest(OGTT)andinsulinreleasingtest(IRT)，andtheirinsu1inresistancewaseva1uatedusinginsulinresistanceindexwithhomeostaticmodelassessment(HOMA).ResultsTheo

6、ccurrencerateofimpairedglucosetoleranceinwomenwithM0Fwas1O.87%，whichwassignificalitlyhigherthanthatincontrolgrouP(3.33%，P<005)Therateofinsulinresistancewas3O.43%inexPerimentalgrouPandlo.00%incontrolgrouP.Theresultsshowedthattherewasasignificantdifferencebetweenthe

7、twogrouPs(P<0.05)。ThelevelsofFSH，LH，PRL，E:，TandpbetweentwogrouPshadnosignificantdifferences(P>0.05).BMIinwomenwithimPairedglucosetolerancewascorrelatedpositivelytoinsulinresistance(r=0.567，P<0.05).ConclusionWomenwithunitarymultiPleovarianfolliclessufferfromsomewha

8、tabnormalglucosemetabolismProbablyduetoobesityandchangedinsulinresistanceThus，forobesewomenwithMOF，0GTTshouldbesuggestedtomonitortheirglucosemetabolismc