wegener肉芽肿双侧穿孔性巩膜软化及周边角膜变薄

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1、万方数据IntJOphthalmol，V01．9，No．7，Jul．2009w删．UO．cnTel：029-8224517283085628Email：IJO．2000@163．com·Casereport·Bilateralscleromalaciaperforansandperipheralcorneal-’‘‘●IT7■’·‘thinninglnWegener7sgranulomatosisscReddy，ITajunisah，TRohanaDepartmentofOphthalmology，Facultyo

2、fMedicine，UniversityofMalaya，KualaLumpur，MalaysiaCorrespondenceto：SCReddy．DepartmentofOphthalmology，UCSISchoolofMedicine，BukitKor，MukimRusila，21600Marang，Terengganu，Malaysia．profscreddy@gmail．cornReceived：2009．04-20Accepted：2009—06-22Abstract·Ararecaseofbilate

3、raIscleromalaciaperforans．bilateraIperipheralcornealthinning(contactlenscornea)andunilateraIorbitaIinflammatorydiseaseina50yearoldfemalepatientwithanindolentformWegener’sgranulomatosis(WG)involvinglungsandsinusesisreported．Thepatientsurvivedfor12yearsafterthei

4、nitiaIdiagnosisofsystemicdisease．TherewasperforationofleftglobefollowingtraumaandnoperforationoftherightglobetilltheIastfoIlowupofthepatient．·KEY＼／VORDS：WegeneYsgranulomatosis；scleromalaciaperforans；peripheralthinningofcornea；proptosisDOI：10．3969／1．issn．1672-5

5、123．2009．07．007ReddySC，TajunisahI，RohanaT．BilateralscleromalaciapefforansandperipheralcornealthinninginWegenefsgranulomatosis．IntJOphthalmol(aHojiYnnkeZnzhi)2009；9(7)：1239-1242INTRoDUCTloNw盖淼=：：=舒：墨二：：da冒伦：盅=inflammationofupperandlowerrespiratorytract，necrotiz

6、ingvasculitisandnephritis．Thediseaseexistsintwoforms；anindolentform(1imited，local—regional，withabsenceofrenalinvolvement)andfulminateform(active，generalized)．Ocularinvolvementcanoccurinbothformsofthedisease，withareportedincidencerangingfrom28％to60％ofcasesandas

7、hishas87％atsometimeduringthepatient’slife．Itmaybepresentatthetimeofdiagnosisorinfactmaybethepresentingfeaturein8％to16％ofpatients⋯¨．ThemostoomnlonocularlesionsobservedinWGpatients撇orbitalinflammatorydisease，necrotizingscleritisandperipheralulcerativekeratitis．O

8、rbitalinvolvementismanifestedasproptosisandisduetoprimarygranulomatousinflammationorcontiguousspreadofthediseasefromadjacentparanasalsinuses．Peripheralulcerativekeratitisisadestruc