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1、Felineinfectiousperitonitis猫传染性腹膜炎KatrinHartmannProf.Dr.med.vet.,Dr.habil.,Dipl.ECVIM-CALudwigMaximilianUniversityMunich,Germany„Jefferson“BSH,11months,maleneutered英国短毛猫，11个月，雄性去势presentingcomplaints主诉-morequietsince3weeks,nowverylethargic持续3周过于安静，现在嗜睡-intermit
2、tendfever,weightloss,thoraciceffusion间歇热，体重下降，胸腔渗出JeffersonWhatisFIP?什么是FIP?felineinfectiousperitonitis(FIP)猫传染性腹膜炎WhatisFIP?什么是FIP?felineinfectiousperitonitis(FIP)causedbyafelinecoronavirus(FCoV)猫传染性腹膜炎是由猫冠状病毒引起的jfelineenteralcoronavirus猫肠道冠状病毒(FECV)jFIPvirus猫传染
3、性腹膜炎病毒(FIPV)Herreweghetal.,1995HowdoesFIPdevelop?FIP如何发生？bychancemutation变异⇒deletioninthe3Cor7Bgene3C或7B基因的缺失Herreweghetal.,1995;Vennemaetal.,1995notatthesamelocation移位⇒abilitytobindtoribosomesinmacrophages能结合到巨噬细胞核糖体上⇒replicationinmacrophages在巨噬细胞中进行复制=>FIP猫传染性腹
4、膜炎WhydoonlysomecatsdevelopFIP?为什么仅有一部分猫会发传染性腹膜炎?increasedintestinalvirusreplication肠道病毒复制的增强=>increasedriskofmutation增加了病毒变异的风险factorsinfluencingreplication影响复制的因素-youngage年龄较小-geneticpredisposition(felineleukocyteantigencomplex?)遗传因素（猫白细胞抗原合成物?）-compromisedimmun
5、esystem免疫抑制-virulenceofthevirus病毒毒力-amountofvirus病毒量-re-infectionrateinmultiplecathouseholds多猫家庭的反复感染几率HowimportantisFIP?FIP有多重要？felineinfectiousperitonitis(FIP)猫传染性腹膜炎-commondisease常见疾病-frequentreasonforreferral:就医常见原因：approximately1ofevery200newfelinecasesprese
6、ntedtoAmericanVeterinaryTeachingHospitalsRohrbachetal.,2001在美国兽医教学医院，每200个新来病例就有1只患本病（2001）Retrospectivestudy(1997–2007)回顾性研究（1997-2007）catswithFIP患传染性腹膜炎的猫659cats(1979–2007)659只猫（1979-2007）diagnosisconfirmedbyhistopathologyand/orimmunohistochemicalstaining通过病理组织
7、学和（或）免疫组化染色确诊controlgroup对照组11582cats(2000–2007)11582只猫（2000-2007）clinicpopulation临床患者数量Environmentalconditions环境因素品种breeding2%宠物密度petstore3%住处shelter18%室外outdoor37%只在室内indoor-only40%01020304050的诊断„Jefferson“BSH,11months,maleneutered英国短毛猫，11个月，雄性
jpresentingcomp
8、laints主诉-morequietsince3weeks,nowverylethargic持续3周过分安静，现在嗜睡-intermittendfever,weightloss,thoraciceffusion间歇性地发热，体重下降，胸部有渗出Jefferson1.clinicalsigns临床症状2.laborat
