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1、TheJournalofInternationalMedicalResearch2009;37:927–938ComparativeAnalysisofProteinExpressioninDifferentiatedThyroidTumours:aMulticentreStudyH-SLIANG1,3,Y-HZHONG1,Z-JLUO4,YHUANG5,H-DLIN6,MLUO7,S-ZHAN2,H-XSU1,S-BZHOU1ANDK-QXIE31DepartmentofEndocrinology,and2DepartmentofPathology,Ni
2、nthAffiliatedHospital,GuangxiMedicalUniversity,Beihai,China;3DepartmentofEndocrinology,NanfangHospital,SouthernMedicalUniversity,Guangzhou,China;4DepartmentofEndocrinology,FirstAffiliatedHospital,GuangxiMedicalUniversity,Nanning,China;5DepartmentofHepatobiliaryandEndocrineSurgery,
3、GuangxiPeople’sHospital,Nanning,China;6DepartmentofHepatobiliaryandEndocrineSurgery,GuangxiPingnanPeople’sHospital,Pingnan,China;7ShanghaiEndocrineandMetabolismResearchInstitute,Shanghai,ChinaThisstudycomparedclinicalfeaturesandthyroidcarcinomas,andoverexpressionofproteinexpressio
4、nprofilesindifferentiatedfragilehistidinetriad(FHIT),p16andE-thyroidtumourstoidentifyproteincadherininthyroidadenomas.Multiplemarkerswiththepotentialforindicatingfactorbinarylogisticregressionanalysismalignancystatus.TissuemicroarraysindicatedthatMMP-2,HBME-1,p16andwereconstructed
5、using119thyroidtumourFHITwereindependentlyrelatedtosamples(45papillarycarcinomas,26differentiatedthyroidtumours.Receiver–follicularcarcinomas,48adenomas).operatingcharacteristicsforthesefourGenerally,therewasoverexpressionoffactorsshowedHBME-1asbestforproliferatingcellnuclearantig
6、en(PCNA),diagnosticaccuracy.Sensitivityandp53,matrixmetalloproteinase(MMP)-7,specificitywereenhancedusinganHBME-HectorBattiforamesothelial-1(HBME-1),1andp16cluster.HBME-1expressionwasMMP-2,pituitarytumour-transformingnotsignificantlydifferentforpapillaryandgene(PTTG)andhumantelome
7、rasefollicularcarcinomas,whereasp16reversetranscriptase(hTERT)inmalignantexpressionwassignificantlyspecific.KEYWORDS:DIFFERENTIATEDTHYROIDTUMOURS;CARCINOMAS;ADENOMAS;DIAGNOSIS;SENSITIVITY;SPECIFICITY;IMMUNOHISTOCHEMISTRY;PROTEINEXPRESSIONIntroductionimaginginvestigations.NumerousT
8、hyroidneoplasmsareverycommonresea
