中药复方ZDS对烧伤大鼠门静脉血清SOD、MDA的影响-论文.pdf

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1、昆明医科大学学报2014，35(2)：5～7CN53—1221／RJournalofKunmingMedicalUniversity中药复方ZDS对烧伤大鼠门静脉血清SOD、MDA的影响张栩”，徐锦雄2)，李锦鸣”，汪虹，王丽，陈斌(1)昆明医科大学第二附属医院中医科；2)烧伤科，云南省烧伤研究所，云南昆明650101；3)昆明医科大学，云南昆明650500)[摘要]目的探讨中药复方ZDS对烧伤后消化道氧自由基损害的保护作用．方法2O只sD大鼠随机分为中药复方ZDS组(ZDS，n=lO)和单纯烫伤组(Con，n：10)，复

2、制30％TBSAIll度烫伤模型后分别于伤后2h开始给予ZDS或温水灌喂，2mL／次，2次，d．并于伤后第3、9天观察门静脉血清超氧化物歧化酶(SOD)活力、丙二醛(MDA)水平、肠外组织器官细菌移位率(BT)及肠粘膜病理学改变．结果ZDS组伤后第9天门静脉血清SOD活力显著高于Con组(P

3、4)02-0005-03EfectsofChineseMedicineCompoundZDSonSerumSODandMDAofBurnRatsZHANGXu”，XUJin-Xiong∞，LIJin-ming”，WANGHong，WANGLi，CHENBin∞(1)Dept．ofTraditionalChineseMedicine；2)Dept．ofBurnsSurgery，The2ndAffiliatedHospitalofKunmingMedicalUniversity，KunmingYunnan6501013)Kun

4、mingMedicalUniversity，KunmingYunnan650500．Chin[Abstract]ObjectiveToinvestigatetheprotectiveeffectsofChinesemedicinecompoundZDSagainstdigestivetactdamagecausedbyoxygenfreeradicalaftertheburns．Methods20SDratswererandomlydividedintoZDS(withZDStreatment，=10)andCon(con

5、trol，n=10)groups．Theratswereinflietedwith30％TBSAfuUthicknessburnonthebackandfedwithChinesemedicinecompoundZDSorwarnlwater(2mL／time．2timesaday)．0nthe3rdand9thpostbumday，theserumsampleswereharvestedfromportalveinandtheserumsuperoxidedismutase(SOD)activity，thelevelso

6、fmalondiadehycle(MDA)weredetected．Meanwhile，thebacteriatransloeationofparenteralorgansandthehistologyofintestinewerealsoobserved．ResultsTheSODactivityinZDSgrouponday9postburnincreasedsignificantlythanthatinCongroup(P<0．05)；butatthesametimepoint，comparedwithCongrou

7、p，theMDAlevelinZDSgroupwasdecreasedobviously(P<0．05)．ConclusionChinesemedicinecompoundZDScanpartlyprotectthedigestivetactagainstdamagecausedbyoxygenfreeradicalaftertheburns．1KeywordsjChinesemedicinecompound；Bums；SOD；MDA烧伤及严重创伤可引发的肠缺血一再灌注损能不全综合征(multipleorgandysfun

8、ctionsyndrome，害可导致肠屏障功能受损、肠腔细菌／内毒素移MODS)【l12】．因此有学者将肠道称为外科应激的中位，进而引发全身炎症反应综合征(systemic心器官和多器官功能衰竭的“始动器官”．其中inflammatoryresponsesyndrome，SIRS)甚至多器官功氧自由基对