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1、绻沙坦联合依那普利治疗2型糖尿病合并原发性高血压的临床观察作者：陈寒放，靳晨亭单位：510640广州，华南理工大学医院内科(陈寒放)；广东药-学院第一附属医院心内科(靳晨亭)【摘要】目的观察纟颉沙坦联合依那普利対2型糖尿病(DM)合并原发性高血压(EH)患者的降压效果及对胰岛素抵抗、尿微最白蛋白、肾功能的影响。方法65例2型DM合并EH患者随机分为缄沙坦与依那普利联合组(治疗组,233)和单用依那普利组(对照组,n=32),疗程均为24周。比较治疗前后2组患者的收缩压(SBP)、舒张压(DBP)、尿微量白蛋白(Alb)、血肌酊(Scr)、血尿素氮
2、(BUN)、空腹血糖(FBG)、空腹胰岛素(FBI)、胰岛素敏感指数(ISI)及劳物不良反应。结果治疗纽•与对照纽降压总有效率分别为87.9%和65.6%,治疗组降压效果优于对照组,差异有统计学意义(PV0.05或PV0.01)。2组治疗后FBI、Alb、Scr、BUN等均降低，ISI升高，与治疗前比较差异有统计学意义，口治疗纽优于对照组(P<0.05或P<0.01)o结论纟颉沙坦联合依那普利治疗2型DM合并EH更加合理有效，而口无明显不良反应。【关键词】纟颉沙坦；依那普利，糖尿病，2型；高血压，原发性Effectofvalsartancombi
3、nedwithenalaprilonpatientswithtype2diabetesmellituscomplicatedwithessentiidhypertensionCHENHanfang,JINChenting.DepartmentofCardiology,AffiliatedHospitalofSouthChinaTechnologicalUniversity,Guangdong,Guangzhou510640,China【Abstract]ObjectiveToobservetheeffectofvalsartancombinedw
4、ithenalpaprilonbloodpressurejnsulinresistance,urinemicroalbuminandkidneyfunctioninpatientswithtype2diabetesmellituscomplicatedwithhypertension.Methods65patientswithtype2diabetesmellituscomplicatedwithhypertensionwererandomlydividedintotwogroups:treatmentgroup(n=33)andcontrolg
5、roup(n=32).33patientsintreatmentgroupweretreatedbyvalsartancombinedwithenalapril;32patientsincontrolgroupweretreatedbyenalaprilonly,withatreatmentcourseof24weeksforbothgroups.Thesystolicbloodpressure(SBP),diastolicbloodpressure(DBP)jnicroalbumin(Alb),serumcreatinine(Scr),bloo
6、dureanitrogen(BUN),fastingbloodglucose(FBG),fastingbloodinsulin(FBI)Jnsulinsensitiveindex(ISI)anddrugadversereactionsweredetectedbeforeandafterthetreatmentinbothgroups.ResultsThetotaleffectiverateintreatmentgroupwas87.9%,whichwas65.6%incontrolgroup.Thetherapeuticeffectoftreat
7、mentgroupwassignificantlysuperiortothatofcontrolgroup(P<0.05).Meantime,therewereobviousdifferencesinthedecreaseofFBI,Alb,Scr,BUNandtheincreaseofISIbeforetreatmentandaftertreatment(P<0.05),moreover,treatmentgroupwassuperiortocontrolgroup(P<0.05orP<0.01).ConclusionValsartancomb
8、inedwithenalaprilisreasonableandeffectiveintreatingtype2diabetesmell
