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时间:2020-04-25
《偏头痛预防性药物治疗降低血清谷氨酸水平研究-论文.pdf》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、·298·临京医学工露2014年3月馅21卷第3期·论著·(临床研究)偏头痛预防性药物治疗降低血清谷氨酸水平研究刘冈,罗东红,陈艳华(广东省珠海市第五人民医院神经内科,广东珠海519055)【摘要】目的探讨谷氨酸在偏头痛中发病机制的作用及水平变化。方法抽选珠海市平沙医院门诊或者住院诊断为偏头痛患者6O例.随机分组分为预防性药物治疗组(应用西比灵治疗)和常规药物治疗组,各3o例。同时选择60例健康人员作为对照组.不进行任何药物治疗。测量所选对象体内血清谷氨酸水平,比较偏头痛及对照正常组患者用药前及用药后8w血浆中谷氨酸水平及用药前后头痛发作时间。同时对比治疗组两种方法治疗后患者头痛发作
2、频率。结果药物使用前,治疗组患者谷氨酸水平为(235.6±25.6)/xmol/L,明显高于对照组,尸0.05;治疗后.预防性药物治疗组患者谷氨酸水平明显降低,发作频率明显减少,与对照组相比,P3、ucingtheLevelofSerumGlutamateLIUGong,LUODonghong,CHENYonhua(NeurologyDepartment,the聊PeopleHospitalofZhuhai,Zhuhai519055,China)【Abstract]ObjectiveToinvestigatethechangesoffunctionandthelevelofglutamateinmigrainepathogenesis.MethodsSixtypatientswithmigraine(treatmentgroup)wererandomlydividedintop4、rophylacticgroup(treatedwithflunarizine)andconventionalgroup(treatedwithconventionaldrug),with30casesineachgroup.Sixtyhealthypeoplewereselectedasthecontrolgroup,anddidnotreceiveanytherapy.TheserulTlglutamatelevelsofthreegroupsweredetected,andthetimeandfrequencyofheadacheepisodesofpatientswithmi5、grainewerecompared.ResultsBeforetreatment,theglutamatelevelsintreatmentgroupwere(235.6±25.6)/zmol/L,significantlyhigherthanthatincontrolgroup,P<0.01;8waftertreatment,thetreatmentgroupglutamateleveldecreasedsignificantly,comparedwiththecontrolgroup,P>0.05.Aftertreatment,thelevelsofglutamateinpro6、phylacticgroupweresignificantlylower,andseizurefrequencyreducedincontrasttothecontrolgroup,P<0.05.ConclusionsGlutamatelevelinpatientswithmigraineisobviouslyimproved,preventivedrugscansignificantlyreduceglutamatelevels,reduceheadachefrequency.[Keywords】Migraine;Glutamate;Preventivedrugs偏头痛为慢性的神经7、血管疾患,严重影响患者生活质量_1]。头痛诊断标准(根据第二届标准抽选)。③患者均无药物过尽管偏头痛未危及生命,但是可以逐渐进展成慢性偏头痛,导敏史,并且积极配合治疗,定时完成随访工作。致更多的功能障碍,影响患者正常生活状态。研究其发病机同时选择同期健康对照组患者.不使用药物治疗,人选条制。可有效指导临床治疗方案的设立,针对性地缓解患者疼痛件为:①头痛间歇期至少2个月;②前后抽血期间未服用任何感,降低其发作频率。经研究表明,谷氨酸水平增加与发病有药物;③无
3、ucingtheLevelofSerumGlutamateLIUGong,LUODonghong,CHENYonhua(NeurologyDepartment,the聊PeopleHospitalofZhuhai,Zhuhai519055,China)【Abstract]ObjectiveToinvestigatethechangesoffunctionandthelevelofglutamateinmigrainepathogenesis.MethodsSixtypatientswithmigraine(treatmentgroup)wererandomlydividedintop
4、rophylacticgroup(treatedwithflunarizine)andconventionalgroup(treatedwithconventionaldrug),with30casesineachgroup.Sixtyhealthypeoplewereselectedasthecontrolgroup,anddidnotreceiveanytherapy.TheserulTlglutamatelevelsofthreegroupsweredetected,andthetimeandfrequencyofheadacheepisodesofpatientswithmi
5、grainewerecompared.ResultsBeforetreatment,theglutamatelevelsintreatmentgroupwere(235.6±25.6)/zmol/L,significantlyhigherthanthatincontrolgroup,P<0.01;8waftertreatment,thetreatmentgroupglutamateleveldecreasedsignificantly,comparedwiththecontrolgroup,P>0.05.Aftertreatment,thelevelsofglutamateinpro
6、phylacticgroupweresignificantlylower,andseizurefrequencyreducedincontrasttothecontrolgroup,P<0.05.ConclusionsGlutamatelevelinpatientswithmigraineisobviouslyimproved,preventivedrugscansignificantlyreduceglutamatelevels,reduceheadachefrequency.[Keywords】Migraine;Glutamate;Preventivedrugs偏头痛为慢性的神经
7、血管疾患,严重影响患者生活质量_1]。头痛诊断标准(根据第二届标准抽选)。③患者均无药物过尽管偏头痛未危及生命,但是可以逐渐进展成慢性偏头痛,导敏史,并且积极配合治疗,定时完成随访工作。致更多的功能障碍,影响患者正常生活状态。研究其发病机同时选择同期健康对照组患者.不使用药物治疗,人选条制。可有效指导临床治疗方案的设立,针对性地缓解患者疼痛件为:①头痛间歇期至少2个月;②前后抽血期间未服用任何感,降低其发作频率。经研究表明,谷氨酸水平增加与发病有药物;③无
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