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时间:2020-04-21
《紫杉醇联合奈达铂治疗中晚期卵巢上皮性癌的疗效分析.pdf》由会员上传分享,免费在线阅读,更多相关内容在应用文档-天天文库。
1、·1830·JournalClinicalandExperimentalMedicineVo1.12,No.22Oct.2013[17]ShinDS,YoonSM,KimSH,eta1.OpenSurgicalEvacuationofSpon·KoreanNeurosu~Soc,2008,44(1):1—7.taneousPutaminalHematomas:PrognosticFactorsandComparison(收稿日期:2013—09—19)ofOutcomesbetweenTranssylvianandTranscorticalApproaches[J].J文章编号:1671—4
2、695(2013)22—1830—03紫杉醇联合奈达铂治疗中晚期卵巢上皮性癌的疗效分析江希萍徐云郭彩霞(苏州大学附属第三医院妇科江苏常州213003)【摘要】目的观察紫杉醇分别联合奈达铂(NDP)及顺铂(DDP)方案对中晚期卵巢癌治疗的近期疗效及不良反应。方法将42例中晚期卵巢癌患者随机分为治疗组和对照组。治疗组:紫杉醇+奈达铂;对照组:紫杉醇+顺铂。分析两组的近期疗效及不良反应。结果治疗组与对照组的近期有效率分别为54.55%和49.00%,差异无统计学意义(P>0.05);治疗组白细胞减少的发生率(55.0o%)和对照组(63.00%),差异无统计学意义(P>0.05);治疗组血小板减少
3、发生率(36.40%)高于对照组(25.00%),但无显著性差异(P>0.05);治疗组胃肠道反应发生率(18.20%)低于对照组(85.00%),差异有统计学意义(P<0.05)。结论奈达铂+紫杉醇为中晚期卵巢癌的有效化疗方案。【关键词】卵巢癌紫杉醇顺铂奈达铂Studyontheefficacyofpaclitaxelcombinedwithnedaplatinorcisplatinintreatmentofadvancedovarianc蚰cer.JIANG一ping.XUYun,GUOCai—xia.Department0,Gynecology,TheTirdA~liatedHospi
4、talofSuzhouUniversity,ChangzhouJiangsu213003,China.【Abstract】ObjectiveTocomparetheeficacyandsafetyofpaclitaxelcombinedwithnedaplatin(NDP)一basedregimenwithcisplatin(DDP)一basedregimenintreatmentofpatientswithadvancedovariancancer.MethodsAtotalof42patientswithadvancedovarianc~cerweregivenwithchemother
5、apyincludingnedaplatinpluspaclitaxelorcombinationofcisplatinandpaclitaxe1.Theeficacyandside—e~ctswerecomparedbetweenthesetwogroups.ResultsTheresponsiveratesof2groupswere54.55%and49.oo%respectivelyinnedaplatingroupandcisplatingroup,thereWasnostatisticaldiferencebetweenthem.Theincidenceofleucopeniain
6、nedaplatingroupWaslessthanthatofcisplatingroup(P>O.05).Ane~aincisplatingroupwasmilderthanthatofnedaplatingroup(P>0.05),andgastrointestinaladversereactionsinnedaplatingroupweremilder(P<0.05)thanthoseofothergroups.ConclusionTheapplicationofnedaplatinandpaclitaxelisanefectiveregimenfortreatmentofpatie
7、ntswithadvancedovariancancer.【Keywords]Ovariancancer;Paclitaxel;Cisplatin;Nedaplatin卵巢癌是妇科恶性肿瘤中病死率最高的肿瘤,近年3.5×10/L,血小板≥80×10/L,肝肾功能不超过正常来其患病率呈逐渐上升趋势J。75%的卵巢癌患者就上限1倍。无其他恶性肿瘤病史及放化疗史;无弥漫性诊时已是晚期,因此需采取手术联合化疗的综合治
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