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1、颈腰痛杂志2003年第24卷第5期TheJournalofCervicodyniaandLumbodynia2003,Vol.24No.5-307-cells)能取得最大量的骨生成O在许多实adenoviralvectorcarryingthehumanBMP-22000,25:376-381.验中,包括人类,已经成功的对改良的骨geneinarabbitspinalfusionmodel[J].Calcif[15]~elmGA,SheehanJM,SheehanJP,etal.TissueInt,
2、1998,63:357-360.UtilizationoftypeIcollagengel,demineral-发生因子细胞群进行分离~净化和扩增O[4]KrammCM,Sena-EstevesM,BarnettF~,etizedbonematrix,andbonemorphogenetic[23]和Lieberman等[2]都证实了Reiw等al.Genetherapyforbraintumors[J].Brainprotein-2toenhanceautologousbonelumbar用BMP
3、-2基因转导的骨髓衍生的间充Pathol,1995,5:345-381.spinalfusion[J].JNeurosurg,1997,86:93-[5]LeGalLaSalleG,RobertJJ,BerrardS,et100.质干细胞能在鼠和兔的脊椎旁诱导骨形al.Anadenovirusvectorforgenetransferinto[16]LindM,SchumackerB,SoballeK,etal.成OBoden等[24]则把骨形成的LMP-1基neuronsandgliaintheb
4、rain[J].Science,transforminggrowthfactor-betaenhances因插入异种骨髓细胞,也成功的在兔和1993,259:988-990.fracturehealinginrabbittibiae[J].ActaOr-鼠的脊椎旁诱导了骨形成O有趣的是,采[6]FisherKJ,JoossK,AlstonJ,etal.Recombi-thopScand,1993,64:553-556.nantadeno-associatedvirusformuscledirecte
5、d[17]SolheimE.Growthfactorsinbone[J].Int用LMP-1基因进行转染时,即使浓度比genetherapy[J].NatMed,1997,3:306-Orthop,1998,22:410-416.较低,也能诱发大量的骨形成O这认为是312.[18]AndrewJG,~oylandJA,FreemontAJ,etLMP-1基因表达能上调许多其它骨形[7]CulverKW.Genetherapyformalignantneo-al.Platelet-derivedgro
6、wthfactorexpressionplasmsoftheCNS[J].BoneMarrowTrans-innormallyhealinghumanfractures[J].成生长因子的表达,共同刺激骨形成Oplant,1996,18(Suppl):6-9.Bone,1996,16:455-460.在将来,可以通过基因治疗的方法[8]UristMR.Bone:formationbyautoinduction[19]~elmGA,AldenTD,SheehanJP,etal.在体内诱导强烈的骨形成O
7、BMP4/7和[J].Science,1965,150:893-899.Bonemorphogeneticproteinsandbonemor-[9]UristMR,Nogami~,MikulskiA,etal.Aphogeneticproteingenetherapyinneurologi-BMP2/7的异二聚体的诱发骨形成的潜bonemorphogeneticpolypeptide[J].Calcifcalsurgery:areview[J].Neurosurgery,能要比起其它BMP同型二聚
8、体大的多OTissueRes,1976,21(Suppl):81-87.2000,46:1213-1222.因此,联合应用这两种载体可以显著的[10]WozneyJM,RosenV,CelesteAJ,etal.[20]VaradyP,LiJZ,CunninghamM,etal.改善骨形成活动O可以预见在临床实践Novelregulatorsofboneformation:molecu-MorphologicanalysisofBMP-9genethera-中,联合应
