舒肝顺气丸对胃溃疡、反流性食管炎模型鼠的保护作用.pdf

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1、舒肝顺气丸对胃溃疡、反流性食管炎模型鼠的保护作用吕姗珊，周年华，杨惠，李根，陈晓雪，谯志文，杨超(重庆希尔安药业有限公司，重庆401121)中图分类号R285文献标志码A文章编号1001．0408(2014)23—2121—04DOI10．6039／j．issn．1001—0408．2014．23．04摘要目的：研究舒肝顺气丸对胃溃疡、反流性食管炎模型鼠的保护作用。方法：通过对利血平、无水乙醇、幽门结扎、水应激复制鼠胃溃疡模型；对贲门切开联合半结扎幽门复制大鼠反流性食管炎模型。5个实验均分为正常对照组、模型组、舒肝健胃丸组、化学药对

2、照(西咪替丁／西沙比利)组与舒肝顺气丸高、中、低剂量组。检查胃溃疡模型鼠胃溃疡病变程度，计算溃疡指数或溃疡发生率；测定反流性食管炎模型大鼠血管活性肠肽、血浆胃动素和血清胃泌素含量。结果：与胃溃疡模型组(利血平／无水乙醇导致／水应激)比较，舒肝顺气丸高、中剂量组鼠溃疡指数降低，差异有统计学意义(P<0．01或P<0．05)；与胃溃疡模型组(幽门结扎)比较，舒肝顺气丸高、中剂量组大鼠溃疡发生率降低，差异有统计学意义(尸<0．01或P<0．05)；与反流性食管炎模型组比较，舒肝顺气丸高、中剂量组大鼠血管活性肠肽含量减少，血浆胃动素和血清胃

3、泌素含量增加，差异有统计学意义(P<0．01或P<0．05)。结论：舒肝顺气丸具有较强的改善功能性消化不良症状、治疗胃溃疡的作用。该研究为舒肝顺气丸的再评价及临床应用提供了药理学依据。关键词舒肝顺气丸；胃溃疡；反流性食管炎ProtectiveEffectsofShuganShunqiPillsonGastricUlcerandRefluxEsophagitisModelRatLYUShan—shan，ZHOUNian—hua，YANGHui，LIGen，CHENXiao—xue，QIAOZhi-wen，YANGChao(Chongq

4、—ingHilanPharmaceuticalLimitedCompany，Chongqing401121，China)ABSTRACTOBJECTIVE：TostudytheprotectiveefectofShuganshunqipillsongastriculcerandrefluxesophagitismodelrats．METH0DS：Thegastriculcermodelwasinducedbyreserpine，absoluteethanol，pyloricligationandwaterimmersionstres

5、smethod；therefluxesophagitiswasinducedbycardiotomyandhalfpyloricligation．Theexperimentalratsweredividedintoblankcontrolgroup，modelcontrolgroup，Shuganjianweipillgroup，chemicaldrug(cimetidine／cisapride)group，Shuganshunqipillhigh—dose，medium—doseandlow-dosegroups．Thedegre

6、eofgreatercurvatureulcerongastriculcermodelmice／ratsofwasdetect-ed，andgastriculcerindexwascalculated．ratplasmamotilinandserumgastrincontentonrefluxesophagitismodelofvasoactivein—testinalpeptidewasdetermined．RESULTS：Comparedwithgastriculcergroup(reserpine，absoluteethano

7、landwaterimmersionstressmethod)，gastriculcerindexwasdecreasedinShuganshunqipillhigh-doseandmedium—dosegroups；therewasstatisticalsig—nificance(P<0．01orP<0．05)．Comparedwithgastriculcergroup(pyloricligationmethod)．TheincidenceofulcerswasdecreasedinShuganshunqipillhigh·dos

8、eandmedium—dosegroups：therewasstatisticalsignificance(P<0．01orP<0．05)．Comparedwithrefluxesophagitismodelgroup，thecont