祛风胜湿颗粒提取工艺优选.pdf

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1、·制剂技术·中圉茜20143月20【J第23卷笫6期PreparationTechnologyCinaPharmaceuticalsVo1．23，No．6，March20，2014祛风胜湿颗粒提取工艺优选秦海军，张毅，马玲-．，陈师农，任燕茹(1．安徽省药物研究所，安徽合肥230022；2．安徽省中药研究与开发重点实验室，安徽合肥230022；3．安徽中医药大学药学院，安徽合肥230031)摘要：目的优选祛风胜湿颗粒最佳的提取工艺方法采用，．(3)正交试验设计，以异欧前胡素含量及干浸膏得率为考察指标，筛选祛风胜湿颗粒的醇提最佳_T-艺条件；以甘草酸单铵盐含量及干浸膏得率为考察指标，

2、筛选祛风胜湿颗粒的水提最佳工艺条件；采用单因素试验，优选防风、川芎、藁本和蔓荆子4味药材的最佳提取工艺。结果优选的祛风胜湿颗粒醇提最佳工艺条件为加10倍量70％乙醇，回流提取2次，每次2h；挥发油的提取工艺条件为加8倍量水提取4h；水提最佳工艺条件为加l0倍量水，煎煮2次，每次1h。结论优选的生产工艺合理、可靠，适合现代化大生产。关键词：祛风胜湿颗粒；提取工艺；挥发油；异欧前胡素；甘草酸单铵盐中图分类号：TQ461；R283．6文献标识码：A文章编号：1006—4931(2014)06—0040—04OptimizationofExtractionProcessofQufengSh

3、engshiGranulesQinHaqun一，ZhangYi一，MaLing一，ChenShinong一，RenYanru(，．AnhuiProvincialInstitute’MateriaMedica，Hefei，Anhui，China230022；2．AnhaiProvincialKeyLaboratoryofResearchandDevelopmento，Chi—neseMedicine，Hefei，Anhui，China230022；3．CollegeofPharmacy，AahuiUniversityofChineseMedicineHefei，Anhui，China

4、230031)Abstract：0bjectiveTooptimizethebestextractionprocessofQufengShengshiGranules．MethodsThe厶(3)orthogonalexperimentdesignwasadoptedwiththeisoimperatorincontentandthedryextractyieldastheinvestigatingindexesforscreeningtheoptimumpro—cessconditionsofthealcoholextractionforQufengShengshiGranule

5、s；withtheanlnlouiuYnglycyrrhetatecontentandthedryextractyieldastheinvestigatingindexesforscreeningthebestprocessconditionsofthewaterextractionforQufengShengshiGranules；thesingletactorexperimentwasadoptedtooptimizetheoptimumextractingprocessot4kindsofmedicinalmaterialRadixSaposhnikoviae，Rhizoma

6、Chuanxiong，LigustMRhizomaetRadixandFructusViticis．ResultsTheoptimizedalcoholextractionprocessconditionsofQul~ngShengshiGranuleswereasfollows：adding10timestheamountof70％ethanol，refluxextractingtwice，2heachtime；thevolatileoilextractionconditionswereasfollows：adding8timestheamountof'waterandextra

7、ctingfor4h；theoptimizedwaterextra(‘一tionprocessconditionswereasfollows：adding10timestheamountofwater．decoctingtwiceand1heachtime．ConclusionFheopti—mizedprocessisreasonable，reliableandsuitableformodernmassproduction．Keywords：QufengShengs