酒精肝的治疗方法(Treatment of alcoholic liver).doc

酒精肝的治疗方法(Treatment of alcoholic liver).doc

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时间:2020-04-06

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1、酒精肝的治疗方法(Treatmentofalcoholicliver)Alcoholicliverdiseaseiscausedbylongperiodsofheavydrinking(alcoho1).Afterethanolentersthelivercell,itisoxidizedtoacetaldehydethroughaseriesofenzymes・Excessivedrinking,alargenumberofacetaldehydeonthelivercellshaveobvioustoxicity.Directlyorindirectlyleadtolivercell

2、degeneration,necrosis,andfibrosis,whichcandevelopintocirrhosisinseverecases・Thepathogenesisofalcoholicfattyliverhasbeenprovedinrecentyears:(1)freefattyacidsenterthebloodtoomuch・(2)thenewsynthesisofhepaticfattyacidsincreased・(3)decreaseinoxidationofhepaticfattyacids・(4)threediacylglycerolsynthesis

3、・(5)intracellularlipoproteinreleasedisorderinhepatocytes.Patientswithalcoholicliverdiseaseoftenappearearly:significantweightloss,lossofappetite,nauseaandvomiting,generalmalaise,fever,abdominalpainanddiarrhea,anduppergastrointestinalbleeding.Alcoholiclivernotonlyaffecttheabsorptionandsynthesisofpr

4、oteinandvitamin(malnutrition),malnutritionhasbecomesecondaryfactorsofhepaticcelldamagefurther,interactioncaneventuallyleadtolivercellfattyinfiltration,inflamination,necrosis,theoccurrenceoflivercirrhosis・Ifitisallowedtodevelop,fibrosisandcirrhosisareinevitable,andmanycomplicationscanoccur・Theseco

5、mplicationsareoftenariskfactorforalcoholicliverfailure:1.upperdigestivetracthemorrhage:portalhypertensioncausedbyhepaticalcoholoccurred,uppergastrointestinalbleeding,alsomaybeduetoacutegastricerosion,ulceroresophagealvaricealbleeding(EVB),ifyoucannotdealwithtimelyandeffective,willshockthecrisisof

6、lifeanddeathrisk.2.:alcoholicliverascitesandinfectionbecauseofelectrolyte,osmoticpressure,nutritionandotherfactorsleadtotheemergenceofalargenumberofascites,similartolivercirrhosisandhepatocellularcarcinoma,inpatientswithascites,resultinginaviciousspiralpronetodisorderofelectrolyteortheentiresyste

7、mcrisisledtothedeathoflove.Atthesametime,duetoalcohol,liverdisease,nutritionandvariouscomplications,resultinginlowimmunity,extremelysusceptibletoinfection,especiallypulmonaryinfectionandbacterialspontaneousperitonitis・

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