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1、中华普通外科学文献渊电子版冤圆园员圆年远月第远卷第猿期悦澡蚤灶粤则糟澡郧藻灶杂怎则早渊耘造藻糟贼则燥灶蚤糟耘凿蚤贼蚤燥灶冤袁允怎灶藻圆园员圆袁灾燥造远晕燥援猿窑219窑窑论著窑灵芝孢子对原发性肝癌术后肝功能影响的研究甄作均王峰杰计勇陈应军李杰原李清汉吴志鹏范国勇陈焕伟揖摘要铱目的评估灵芝孢子对原发性肝癌术后肝功能的影响遥方法80例原发性肝癌切除术后患者随机分为对照组(常规护肝治疗)和治疗组(对照组基础上加灵芝孢子治疗),各40例遥术后1d尧3d尧7d动态监测肝功能指标(ALT尧AST尧TBIL尧ALB尧PT)变化
2、,比较灵芝孢子治疗对原发性肝癌术后肝功能的影响遥结果术后第1天,治疗组和对照组均出现较明显的肝功能损害遥经1周治疗后,治疗组较对照组肝功能明显改善(P=0.032),无一例出现肝功能不全,而对照组2例出现肝功能不全遥两组术后并发症和药物不良反应无明显差异(P分别为0.453尧0.874)遥结论灵芝孢子可以较好地改善原发性肝癌患者术后肝功能的损害,改善患者的预后遥揖关键词铱肝功能;肝切除;原发性肝癌;灵芝孢子StudyofGanodemalucidumtreatmentonliverfunctionafterhep
3、aticresectioninpatientswithhepatocellularcarcinomaZHENZuo-jun,WANGFeng-jie,JIYong,CHENYing-jun,LIJie-yuan,LIQing-han,WUZhi-peng,FANGuo-yong,CHENHuan-wei.DepartmentofLiverandPancreaticSurgery,thefirstpeople爷shospitalofFoShan,FoShan528000,ChinaCorrespondingauth
4、or:ZHENZuo-jun,Email:datudou2010@gmail.com揖Abstract铱ObjectiveToevaluateGanodemalucidum(GAL)treatmentonliverfunctionafterhepaticresectioninpatientswithhepatocellularcarcinoma(HCC).MethodsEightypatientswithHCCundergoinghepatectomywererandomlydividedintoGALthera
5、pygroup(40cases)andconventionaltherapygroup(40cases).Thepostoperativeliverfunctiontestsofoneweek(1d,3d,and7d)fortwogroupswereassessed.ResultsTherewereobviousimpairmentsofliverfunctionatfirstdayafterhepaticresectionintwogroups.Afteraweekofprotectivetreatmentfo
6、rliverinjuryafterhepatectomy,theliverfunctionofGALtreatmentgroupwassignificantlyimprovedcomparingtothatofconventionaltreatmentgroup(P=0.032).Twocasesinconventionaltreatmentgroupweremanifestedwithliverdysfunction,butnooneinGALtreatmentgroup.Therewerenosignific
7、antdifferencesincomplicationsofoperation(P=0.453)andside-effectsofdrug(P=0.874)betweenthetwogroup.ConclusionTheGALtreatmenthadfavourableefficacyonreducingimpairmentofliverfunctionafterhepaticresectioninpatientswithHCC.揖Keywords铱Liverfunction;Hepaticresection;
8、Hepatocellularcarcinoma;Ganodemalucidum我国90%的原发性肝癌合并有乙型肝炎和肝硬化,术后肝功能的损害十分明显[1]遥肝癌切除手术不同于其他外科肿瘤根治术,需要考虑肝功能对手术根治的影响[2]遥顾忌术后可能出现严重的肝功能损害,常影响到术中的根治性切除遥快速有效地减少术后肝功能的损害尧促进肝功能的恢复不但可以增加根治性切除的机会,而且
