消滞胃宁治疗慢性萎缩性胃炎及伴发胃癌癌前期病变的药理实验研究.doc

《消滞胃宁治疗慢性萎缩性胃炎及伴发胃癌癌前期病变的药理实验研究.doc》由会员上传分享，免费在线阅读，更多相关内容在工程资料-天天文库。

1、消滞胃宁治疗慢性萎缩性胃炎及伴发胃癌癌前期病变的药理实验研究作者:苑伟，徐培元，赵建邦，马迎春，杨芳【摘要】忖的观察中药消滞胃宁对大鼠慢性萎缩性胃炎（CAG）及胃癌前期病变（PLGC）动物模型胃黏膜血流量（GMBF）及其病变逆转治疗作用°观察消滞胃宁的镇痛、抗炎作用和对免疫功能的影响。方法在大鼠CAG及PLGC动物模型中，用激光多普勒血流计测定大鼠CAG和PLGC的GMBF,同时对各组CAG和PLGC的进行了病理组织学检查；镇痛实验采用小鼠冰酣酸扭体法、热板法、恒温水浴甩尾法；抗炎实验使用二甲苯所致小鼠耳肿胀、小鼠毛细血管渗透性实验；免疫实验采用小白

2、鼠碳粒廓清实验和小鼠血清溶血素实验。结果大鼠慢性萎缩性胃炎及胃癌前期病变动物模型实验中，经消滞胃宁50天的治疗，高剂量组大鼠便瀟消失，动物体重较模型对照组增加明显，模型组较止常组GMBF明显减少，各治疗组均可降低GMBF,消滞胃宁高、中、低剂量组大鼠的胃组织病变得到了明显改善。镇痛实验表明：消滞胃宁能减少小鼠冰醋酸扭体次数；提高小鼠热板痛阈值；能延长小鼠恒温水浴甩尾时间。抗炎实验表明：消滞胃宁减轻二甲苯所致小鼠耳肿胀度；抑制小鼠毛细血管渗透性的增加。免疫实验表明：消滞胃宁能明显提高单核细胞的吞噬功能；增加小鼠H1L清溶血索含量。结论消滞胃宁能提高GA

3、C和PLGC胃黏膜血流量，改善组织病理；消滞胃宁具有明显的镇痛、抗炎作用，并能提高机体免疫力。【关键词】消滞胃宁；慢性萎缩性胃炎；胃癌前期病变；胃黏膜血流量；镇痛；抗炎；免疫ExperimentalresearchofeffectofXiaozhiweiningonchronicatrophicgastritisandprecancetouslesionsofgastriccanceT【Abstract】ObjectiveToexploretheeffectofXiaozhiweiningonGMBFinratswithatrophicgastrit

4、isandprecancerouslesionsofgastriccancerandtostudyitstherapeuticeffects,toexp1oreXiaozhiweiningonpharmacodynamicactionofanti-inflammationandalleviatingpain,andimpactonimmuncfunction.MethodsAcomplexmethodwasusedtoestablishthemodelthatwasstimulatingthevariousfactorstocauseflowmete

5、r.Thedateofdifferentgroupswereanalyzedandcompared.Themixture"spharmacodynamicactionwasmeasuredbyobservingitseffectontorsiversionmalpositionmicewithpaininclucedbyiceacetic.Onthosewithpaininducedbyhotboard,thermostaticalwaterbathtogetridofthetai11awexperimental!y；Resistinflammati

6、onexperimentuseTatsearswelling,ratscapi1larypermeabilityexperimentinducedbyinjectingiceaceticintomiccabdominal；Theimmuneexperimentusesratsclearexp-erimentofcarbon.ResuItsTheexperimentalPLGChavelower，XiaozhiweiningincreasedtheGMBF.Xiaozhiweiningcanmodulatethisstateandimprovethev

7、aTiouspathologicaimanifestationsofCAGand卩LGC.ConclusionXiaozhiwcininghadcffcctofanti-inflammationandallcviatingpain,andcanimprovetheorganism"simmunefunction.[Keywords]Xiaozhiweining；chronicatrophicgastritis；prccanccrouslcsionsofgastTiccanccr；gastricmucosiabloodf1ows；alleviating

8、pain；anti-inf1ammation；immune应用中医药防治慢性萎缩性胃炎(chronicatr