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时间:2017-12-08
《白花败酱草提取物对小鼠前列腺增生的实验研究》由会员上传分享,免费在线阅读,更多相关内容在学术论文-天天文库。
1、2013年11月第20卷第33期·实验研究·白花败酱草提取物对小鼠前列腺增生的实验研究郭晓秋’徐洁曾玲1张文然1曾靖z1.江西省中医院药剂科,江西南昌330006;2.赣南医学院药学院,江西赣州341000【摘要】目的研究白花败酱草提取物(PVJE)对小鼠前列腺增生的抑制作用。方法小鼠随机分为对照组、模型组、普乐安组、小剂量PwE组、大剂量PVJE组。对照组皮下注射花生油溶液0.1ml/只。其余各组均皮下注射丙酸睾酮溶液5mg/(kg·d),同时普乐安组给予5(·d)的普乐安溶液灌胃,小剂量PVJE组、大剂量PVJE组分别给予0.02、0.04g/(kg·d)的白花败酱草提
2、取物溶液灌胃,共给药12d。研究小鼠前列腺湿重、前列腺指数、性激素水平和光镜下前列腺形态学的变化。结果与模型组比较,PVJE能明显抑制由丙酸睾丸酮诱发的小鼠前列腺增生,小鼠血清睾丸酮(T)、和雌二醇(E)含量明显降低。结论PVJE对丙酸睾丸酮所致小鼠前列腺增生具有显著的拈抗作用。【关键词】白花败酱草;提取物;前列腺增生;小鼠【中图分类号】R282.71【文献标识码】A【文章编号】1674-4721(2013)11(c)一0033—02ExperimentalstudyofPatrinaVillosaJuss.extractiveonbenignprostatichyperp
3、lasiamodelofmiceGUOXiao-qiuiXU.1ieiZENGrindZHANGWen—rOltlZENGJin1.DepartmentofPharmacy,HospitalofTraditionalChineseMedicineinJianxiProvince,Nanchang330006;2.Phar.macyCollegeofGannanMedicalCollegeinJianxiProvince,Ganzhou341000,China【Abstract】ObjectiveTostudyinhibitingeffectofPatrinaVillosaJ
4、ussextractive(PVJE)onbenignprostatichyperpla-siaofmice.MethodsMiceweredividedintofivegroupsincludingpositivecontrolgroup,modelgroup,Puleantabletstreatinggroup,lowdosePVJEgroupandhighdosePVJEgroup.Themiceincontrolgroupwereinjectedsubcuta—neouslywithpeanutoilsolution(0.1m1),whileinothergroup
5、stestosteronepmpionatesolution【5mg/(kg·d)】wasem—ployedinsteadoftheoil.MeanwhilePuleangroupwasgivengavagewithPulean5g/(kg·d),andlowdosePVJEgroupandhighdosePVJEgroupweregivenPVJEgarage[0.02,0.04g/(kg‘d)]for12consecutivedays.Wetweightofprostate,prostatehealthindex,sexhormonelevelsandprostatem
6、orphologicalchangesunderlightmicroscopewerecomparedamongdifferentgroups.ResultsComp~edwithmodelgroup,PⅥEcanapparentlyinhibitprostatichyper-plasiainmiceinducedbytestosteronepropionate,reducetheserumtestosterone(T),estrodiol(E2)contents.ConclusionPVJEhavesignificantinhibitingeffectonbenignpm
7、statichyperplasiainducedbytestosteronepropionateinmice.[Keywords】PatrinaVillosaJuss;Extractive;Prostatichyperplasia;Mice白花败酱草(PatrinaVillosaJuss。PVJ)为是败酱科草和抑制胃癌SGC7901细胞生长并诱导其发生凋亡等作本植物的根茎及带根全草,是一种常用植物药,在我国分用[5-。本文研究PVJE对小鼠前列腺增生的作用,报道如下。布极广。败酱科味辛、苦性寒『1】,具有清热利湿、
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