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1、LEEP术后重组人干扰素a-2b阴道泡腾胶囊治疗宫颈高危型HPV感染的疗效分析【摘要】目的对比分析宫颈环形电切术(LEEP)术后重组人干扰素a-2b阴道泡腾胶囊对宫颈高危型人乳头瘤病毒(HPV)感染患者的临床效果。方法96例高级别宫颈上皮内瘤变LEEP术后宫颈高危型HPV持续阳性患者，随机分为对照组和观察组，各48例。观察组患者实施重组人干扰素a-2b阴道泡腾胶囊治疗，对照组崽者未用药治疗。对比两组患者的临床效果。结果治疗前，观察组患者HPV感染率为64.6%,对照组为62.5%,比较差异无统计学意义(x2=0.04,P>0.0
2、5)o治疗后6个月，观察组患者HPV感染率为6.3%,低于？巾兆禍?22.9%,差异具有统计学意义(x2=5.35,P<0.05)o治疗后12个月，观察组患者HPV感染率为0,低于对照组的10.4%,差异具有统计学意义(x2=5.27,P<0.05)o结论重组人干扰素a-2b阴道泡腾胶囊用于LEEP术后宫颈高危型HPV感染的治疗，可以降低多重高危型HPV感染发生率，具有较高的临床价值，值得临床推广。【关键词】重组人干扰素a-2b；高危型人乳头瘤病毒；宫颈上皮内瘤变【Abstract]ObjectiveTocompareandan
3、alyzetheclinicaleffectofrecombinanthumaninterferona-2bvaginaleffervescentcapsuleafterloopelectricalexcisionprocedure(LEEP)inthetreatmentofcervicalhigh-riskhumanpapillomavirus(HPV)infection.MethodsAtotalof96cervicalhigh-riskHPVcontinuouspositivepatientsofhigh-levelcer
4、vicalintraepithelialneoplasiaafterLEEPwererandomlydividedintocontrolgroupandobservationgroup,with48casesineachgroup・Theobservationgroupreceivedrecombinanthumaninterferona・2bvaginaleffervescentcapsulefortreatment,andthecontrolgroupreceivednodrugtherapy・Clinicaleffectw
5、ascomparedintwogroups・ResultsBeforetreatment,theobservationgrouphadHPVinfectionrateas64.6%,whichwas62.5%inthecontrolgroup,andthedifferencehadnostatisticalsignificance(x2=0.04,P>0.05).After6monthsoftreatment,theobservationgrouphadlowerHPVinfectionrateas6.3%than22.9%in
6、thecontrolgroup,andthedifferencehadstatisticalsignificance(x2=5.35,P<0.05)・After12monthsoftreatment,theobservationgrouphadlowerHPVinfectionrateas0than10.4%inthecontrolgroup,andthedifferencehadstatisticalsignificance(x2=5.27,P<0.05)・ConclusionRecombinanthumaninterfero
7、na・2bvaginaleffervescentcapsulehashighclinicalvalueinthetreatmentofcervicalhigh-riskHPVinfectionafterLEEP,anditcanreducetheincidenceofmultiplehigh-riskHPVinfection.Soitisworthyofclinicalpromotion.[Keywords]Recombinanthumaninterferona・2b；High-riskhumanpapillomavirus；C
8、ervicalintraepithelialneoplasias宫颈上皮内瘤变是妇科临床上发生率较高的一种疾病，主要是一种和宫颈浸润癌相关的癌前病变，是宫颈癌发生的前兆［1］。宫颈上皮内瘤变和宫颈癌的发生均与HPV发生感染密切相关。目前临床上对于宫颈上皮内瘤变的
