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时间:2017-12-07
《肠癌患者贫血与肿瘤特征及微血管密度的相关性分析》由会员上传分享,免费在线阅读,更多相关内容在学术论文-天天文库。
1、572肠癌患者贫血与肿瘤特征及微血管密度的相关性分析陆晔程旭李蓉严敏潘湘涛(苏州大学附属太仓医院,江苏省215400)【摘要】目的探讨肠癌患者贫血与肿瘤特征及微血管密度(MVD)表达等关系。方法对59例肠癌患者分别应用常规方法检测血红蛋白(Hb)值,应用免疫组化法检测MVD,并进行相关分析。结果①59例肿瘤患者贫血20例(33.9%)、无贫血39例(66.1%);MVD表达59例(100.O%)。②贫血和无贫血患者的MVD表达差异无统计学意义(P>0.05)。③肠癌患者是否贫血与肿瘤临床分期及肿块大小有关(P<0.05),与患者的性别、年龄、肿瘤分化程度、
2、有无淋巴结转移及MVD表达无关(P>0.05);MVD表达与患者临床分期、肿瘤分化程度、性别、年龄、有无淋巴结转移无关(P均>0.05),但与肿块大小有关(P<0.05)。④Hb值的高低与MVD的表达不相关,(P>0.05)。结论肠癌患者的贫血发生率较高,是否贫血与肿瘤临床分期及肿块大小有关。【关键词】肠癌;贫血;血红蛋白;肿瘤微血管密度(MVD)【中图分类号】R735.3【文献标识码】B【文章编号】1673-7768(2013)06-0572-03Correlationofanemiawithtuinorcharacteristicsandmicrove
3、sseldensityinpatientsthcolorectalcancerLUYe,CHENGXu,LIRong,YANMing,PANXiang-tao(AfiliatedTaicangHospitalofSozhouUniversity,Jiangsu215400,China)【Abstract】ObjectiveTostudythetumorcharacteristicsandmicrovesseldensity(MVD)incolorectalcancer,investigatingtheirrelationshipwithanemia.Met
4、hodsRoutinemethodsandimmunohistochemistrywereusedtodetecthemoglobinandMVDin59casesofeolorectalcancerrespectively,thencorrelationanalysisofthetwoweretaken.Results(~)Among59casesofcolorectalcancer,therewere20patientswithanemia(33.9%),whiletheMVDwerefoundedinallpatients(100%).(~)Ther
5、ewasnOsignificantdiferenceintheexpressionofMVDbetweenthepatientswithorwithoutanemia(P>0.05).③Theoccurrenceofanemiainpatientswithcolorectalcancerwasrelatedtotheclinicalstageandsizeofthetumor(P<0.05),butnottogender,age,diferentiation,lymphaticmetastasisandMVDexpression(P>0.05).Theex
6、pressionofMVDhadnocorrelationwithclinicalstages,diferentiation,gender,age,andlymphaticmetastasis,however,itwasrelatedtotumorsize(P<0.05).(~)TherewasnotcorrelationbetweenHbandMVD(P<0.05).ConclusionTheincidenceofanemiainpatientswitheolorectalcancerishighandtheoccurrenceofanemiawasco
7、relatedtlltheclinicalstagesandsizeofthetumor.【Keywords】ColorectalCancer,Anemia,Hemoglobin,MicrovesselDensity贫血是肠癌患者最常见的合并症之一,并且能够影响括兔抗人FVⅢ抗体相关抗原多克隆抗体、HIGH.SABC试患者的生存质量及预后,贫血与多种因素相关,文献对贫血剂盒、DAB显色试剂盒和APES粘片剂。②采用SABC免疫和肿瘤微血管生成关系的分析结果报道不一。为了研究肠组织化学染色法,所有石蜡标本均进行5m切片,连续切癌贫血的临床特点及其与年龄、性别
8、、肿瘤发生部位、肿瘤4张,置于60℃烤箱内烤30min;分别经二甲
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