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1、#1151#ChinJClinPharmacolTherrFullarticalrChinesePharmacologicalSocietyCN34-1206PR,ISSN1009-2501E-mail:ccpt96@21cn.comOct;12(10):1151-1156PharmacokineticPpharmacodynamicstudiesinanestheticdrug-druginteractions)aresponsesurfacemodelwithremifentanilandsevofluraneforChinese
2、adultpatients12133,4YANGLu,YANGBa-xian,ZHANGL-iping,BIShan-shan,LUWei12DepartmentofAnesthesiology,ThirdHospital,PekingUniversity,Beijing100083,China;DepartmentofAnesthesiology,People.sHospital,PekingUniversity,Beijing100083,China;3DeptartmentofPharmaceutics,SchoolofPhar
3、maceuticalScience,PekingUniversity,Beijing100083,China;4StateKeyLab.ofNaturalandBiomimeticDrugs,Beijing100083,ChinaABSTRACTAIM:TodeterminetheinteractionswithKEYWORDSdrug-druginteractions;synergy;re-response-surfacemodelingmethodologieswhensevoflu-sponse-surfacerane(Sevo
4、)andremifentanil(Remi)wereadministeredsimultaneously.METHODS:(1)Patients,StudydesignItisknownthatthedrug-druginteractionsaretheanddrugdelivery:Basedonparallelslicesdesign,sixty-basisinanestheticpractice.Combiningananalgesicwithfivepatientswererandomlyassignedtoinhaleasp
5、ecificahypnotictoproduceanalgesiaandsedationrequiredinaend-tidalconcentrationofsevoflurane(0.3%to3.4%),generalanesthesiaismorecommonthanadministrationawithdifferentlevelofremifentanil(0-10ngPmL).Thevolatileanestheticagentalone.responsestolaryngoscopywereobservedforeachg
6、ivenInChina,thecombinationofanintravenousanalge-concentrationpair.(2)PharmacokineticPpharmacodynam-sicandaninhalanthypnotichasnotbeenreported.Theicanalysiswithresponsesurfacemode:Theprobabilityofaimsofthisstudyweretodeterminetheinteractionsbe-noresponse(P)wasassessedint
7、hemodelingprocessastweensevoflurane(Sevo)andremifentanil(Remi)whenbelow.thetwodrugswereadministeredsimultaneouslytoChineser(Us+Ur)adultpatientsinageneralanesthesia.Thedrug-drugin-P=rr[U50PI(Q)]+(Us+Ur)teractionswerecharacterizedwithresponse-surfacemode-lRESULTSANDDISCUS
8、SION:NONMEMestimatedingmethodologies.averagevalues(RSE%)ofthemodelparametersforla-1MATERIALSANDMETHODSryngosco
