FERROUS GLYCINATE (processed with CITRIC ACID)-柠檬酸甘氨酸亚铁.pdf

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1、FERROUSGLYCINATE(processedwithCITRICACID)Newspecificationspreparedatthe61stJECFA(2003),publishedinFNP52Add11(2003).Thecompoundissuitableforuseasasourceofiron,providedthatthetotalintakeofirondoesnotexceedtheprovisionalmaximumtolerabledailyintakeof0.8mg/kgofbodyweightforironf

2、romallsourcesallocatedbythe27thmeeting.SYNONYMSFerrousbisglycinateDEFINITIONFerrousglycinateisaniron(II)chelatewithanirontoglycineratioof1:2.Ferrousglycinate(processedwithcitricacid)alsocontainscitricacid.Itismanufacturedbyreactionofreducedironwithglycineinthepresenceofcitr

3、icacid.Theresultingproductisspraydriedwithoutpriorremovalofthecitricacid.Thesubstanceishighlyhygroscopicandmaycontainwaterinvariableamounts.AssayNotlessthan21.6%andnotmorethan23.0%ofiron(II)onthedriedbasisDESCRIPTIONAfree-flowing,greygreen,hygroscopic,finepowder.FUNCTIONALU

4、SESNutrientCHARACTERISTICSIDENTIFICATIONSolubility(Vol.4)Freelysolubleinwater,practicallyinsolubleinacetoneandinethanolFerrousion(vol.4)PassestestInfraredspectrum(Vol.4)Theinfraredspectrumofapotassiumbromidedispersionofthesampledriedat105°overnightcorrespondstothereferencei

5、nfraredspectrumbelow.PURITYLossondrying(Vol.4)Notmorethan9%(105°,3h)CitricacidNotmorethan19.5%onthedriedbasisSeedescriptionunderTESTSTotalironBetween19and24%onthedriedbasisSeedescriptionunderTESTSFerricironNotmorethan4%onthedriedbasisSeedescriptionunderTESTSNitrogen(Vol.4)B

6、etween11and12%onthedriedbasisLead(Vol.4)Notmorethan1mg/kgDetermineusinganatomicabsorptiontechniqueappropriatetothespecifiedlevel.TheselectionofsamplesizeandmethodofsamplepreparationmaybebasedontheprinciplesofthemethoddescribedonVolume4,"Instrumentalmethods".TESTSPURITYTESTS

7、CitricacidDeterminebyHPLCusingthefollowingconditions:Column:C18reversedphase(4.6x100mm)Detection:UVat206nm.Mobilephase:acetonitrile:0.1Mdiammoniumhydrogenphosphate(3:97).Flowrate:1.0ml/min.Injection:10µl.Runtime:10min.Retentiontimeforcitricacid:about3min.0.1Mdiammoniumhydro

8、genphosphate:Aqueoussolutionof13.20g/lofdiammoniumhydrogenphosphate,(NH4)2HPO4,pHa