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1、AVIANINFLUENZA“Thepandemicinfluenzaclockisticking.Wejustdon’tknowwhattimeitis.”LaureneMascola,MD,MPH,FAAPAcuteCommunicableDiseaseControlProgramDHSD12:AvianFlu.pptNo.1AcuteCommunicableDiseaseControlProgramOUTLINEÑBackgroundonInfluenzaAÑImpactofinfluenzaÑPandemicsÑAvianinflue
2、nzaAvirusesÑHumaninfectionswithavianinfluenzaAvirusessince1997ÑH5N1Asia2005TimUyeki,MDDHSD12:AvianFlu.pptNo.2AcuteCommunicableDiseaseControlProgramBACKGROUND:HUMANINFLUENZAÑAcutefebrilerespiratoryillnessVSymptoms,signsmaydifferbyageÑEtiology:infectionwithhumaninfluenzavirus
3、es(infectupperrespiratorytractepithelialcells)V2majorsurfaceglycoproteins°Hemagglutinin,Neuraminadase°8genesegmentscodefor10proteinsÑTypesAandBvirusescausesubstantialillnessanddeathamonghumansyearlyTIMUyeki,MDDHSD12:AvianFlu.pptNo.3AcuteCommunicableDiseaseControlProgramEPID
4、EMIOLOGYÑShortincubationperiod,usually1-4days.ÑSpreadbyrespiratorydroplets―person-to-person,directcontact,rareaerosolÑHighlycontagious;infectiousperiod:VAdults:1daypriortosymptomsthru5dayspostillnessVChildren:>10daysVImmunecompromisedshedvirusforweekstomonthsÑVirus1stdetecta
5、blejustbeforesymptomonset.Usuallynotdetectableafter5-10daysDHSD12:AvianFlu.pptNo.4AcuteCommunicableDiseaseControlProgramKEYINFLUENZAVIRALFEATURESSurfaceproteins(majorantigens)ÑHemagglutinin(HA)HAVSiteofattachmenttohostcellsNAVAntibodytoHAisprotectiveÑNeuraminadase(NA)VHelps
6、toreleasevirionsfromcells-oseltamavirworkshereVAntibodytoNAcanhelpmodifydiseaseseverityTimUyeki,MDDHSD12:AvianFlu.pptNo.5AcuteCommunicableDiseaseControlProgramIMPACTOFINFLUENZAÑSeasonalepidemicsintemperateregionsVU.S.,Canada,Europe,Russia,China,Japan,Australia,Brazil,Argent
7、inaÑYear-roundactivityintropicalclimatesVEquatorialAfrica,SoutheastAsiaÑU.S.impactVAverageof>200,000influenza-relatedhospitalizations/yearVAverageof>36,000influenza-relateddeaths/yearÑ3globalpandemicsinthe20thcenturyTimUyeki,MDDHSD12:AvianFlu.pptNo.6AcuteCommunicableDisease
8、ControlProgramINFLUENZAPANDEMICS20THCENTURYCredit:USNationalMuseumofHealtha
