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1、BestofASCOinChina LungCancerSession3ProfessorTonyMokDept.ofClinicalOncologyTheChineseUniversityofHongKongHongKong,ChinaChemotherapyBettercytotoxicdrugNewercombinationwithtargetedtherapyLongerdurationoftreatmentChemotherapyBettercytotoxicdrugPhaseIIIstudyonnab-paclitaxel(Aba
2、xane)NewercombinationwithtargetedtherapyPhaseIIIstudyoncombinationoffigitumumab(IGFR1inhibitor)andchemotherapyLongerdurationoftreatmentMaintenancegemcitabineaftergem/carboResultsofaRandomized,PhaseIIITrialofnab-PaclitaxelandCarboplatinComparedWithCremophor-basedPaclitaxelan
3、dCarboplatinasFirst-lineTherapyinAdvancedNon-smallCellLungCancerAbstract#LBA7511MASocinski,1IBondarenko,2NAKaraseva,3AMMakhson,4IOVynnychenko,5IOkamoto,6JHon,7VHirsh,8PBhar,9JIglesias91LinebergerComprehensiveCancerCenter,UniversityofNorthCarolinaatChapelHill,NC,USA;2CityHos
4、p#4,Dnepropetrovsk,Ukraine;3CityOncologyCenter,St.Petersburg,Russia;4CityOncologyHospital#62,Moscow,Russia;5RegionalOncologyCenter,Sumy,Ukraine;6KinkiUniversitySchoolofMedicine,Osaka-Sayama,Japan;7ClearviewCancerInstOncSpecialties,P.C,Huntsville,AL,USA;8McGillUniversity,Mon
5、treal,Quebec,Canada;9AbraxisBioScience,LosAngeles,CAnab-PaclitaxelWithCarboplatin(nab-P/C)inAdvancedNSCLC:ADose-findingNonrandomizedPhaseIIA7armtrialinvestigatedthesafetyandefficacyofnab-P/Catbothweeklyandq3wdosingschedules(Socinski,JTO5:852-61,2010)Weeklynab-paclitaxel(100
6、mg/m2d1,8,15)pluscarboAUC6q3wdemonstratedoptimaltherapeuticindexRR=48%,medianPFS=6.2months,medianOS=11.3monthsGrade3/4toxicity:neutropenia64%,neuropathy8%,thrombocytopenia20%,anemia16%BasedonthephaseIIresults,aphaseIIItrialwasdesignedtoinvestigatetheefficacy/safetyofnab-P/C
7、vsP/Casfirst-linetherapyinadvancedNSCLCPhaseIIInab-P/CvsP/CStudyDesignChemo-naivePS0-1StageIIIb/IVNSCLCN=1,050Stratificationfactors:Stage(IIIbvsIV)Age(<70vs>70)SexHistology(squamousvsnonsquamous)Geographicregionnab-Paclitaxel100mg/m2d1,8,15CarboplatinAUC6d1NoPremedicationn=
8、5251:1Paclitaxel200mg/m2d1CarboplatinAUC6d1WithPremedicationofDexamethasone+Antihi
