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1、미백화장품의소재Skinwhitening재약공학•20082321•조량kinwhitening,skinlighteningandskinbleachingreferstothepracticeofusingchemicalsubstancesinanattempttolightenskintoneorprovideanevenskincomplexionbylessentheconcentrationofmelanin.Severalchemicalshavebeenshowntobeeffectiveinskinwhitening.
2、UsesSpecificzonesofabnormallyhighpigmentationsuchasmolesandbirthmarksmaybedepigmentedtomatchtothesurroundingskin.Conversely,incasesofvitiligo,unaffectedskinmaybelightenedtoachieveamoreuniformappearance.However,incaseswherethesespottreatmentcreamsareusedinattempttolightenth
3、eentirecomplexion,allofthecurrentmethodsareconsideredineffective.Completeskindepigmentationissimplyafutileprocess.Anadditionalapplicationisgenitaloranalbleaching,intendedtoreducethetypicallydarkerpigmentationofthegenitalandperianalarea.Longtermuseofskinwhitenerscanleadtopi
4、gmentationincreasingtothejointsofthefingers,toes,buttocksandears.Theskinofthefacecanbecomethinnedandtheareaaroundtheeyescanhaveincreasedpigmentationcausinga'bleachpandaeffect'.CombinationtreatmentsMostskin-lighteningtreatments,whichcanreduceorblocksomeamountofmelaninproduc
5、tion,areaimedatinhibitingtyrosinase.Manytreatmentsuseacombinationoftopicallotionsorgelscontainingmelanin-inhibitingingredientsalongwithasunscreen,andaprescriptionretinoid.Dependingonhowtheskinrespondstothesetreatments,exfoliants—eitherintheformoftopicalcosmeticorchemicalpe
6、els—andlasersmaybeused.NewdevelopmentusingLEDsystemsarealsoshowinggoodresults.HomemadetreatmentsManypeopletheworldoverusehomemadetreatmentsforawhiterskin,ratherthanbuycommercialskinlighteners.Thesehomemadetreatmentsincludeextractsoflemonjuice,milk,lime,licoriceandotherherb
7、s.MercuryManyskinwhitenerscontaintoxicmercurysuchasmercury(II)chlorideorammoniatedmercuryastheactiveingredient.Howevermercuryhasbeenbannedinmostcountries(Europe1976)(USA1990)foruseinskinwhiteningbecauseitaccumulatesonskinanditcanhavetheoppositeresultsinthelongterm.Somestud
8、iessuggestthatlong-termusecouldcausesystemicabsorptionthatleadstotissueaccumulationofthes
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