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ID:52208057
大小:12.08 MB
页数:48页
时间:2020-04-02
《绿色化学课件Ch6.ppt》由会员上传分享,免费在线阅读,更多相关内容在教育资源-天天文库。
1、Chapter6:ProspectsandChallengesinGreenChemistry0403809GreenChemistryChapter6:ProspectsandChallengesinGreenChemistryZ.Weng0403809GreenChemistryChapter6:ProspectsandChallengesinGreenChemistryZ.WengOutline6.1KeyGreenChemistryResearchAreas6.2AmideFormation:avoidingpoorat
2、omeconomyreagents6.3AlcoholActivationforNucleophilicSubstitution6.4Reductionofamideswithouthydridereagents6.5Oxidation/EpoxidationMethods6.6C–HActivation6.7AsymmetricSynthesisofAminesfromProchiralKetones6.8Asymmetrichydrogenationofunfunctionalisedolefins/enamines/imi
3、nes6.9NewGreenerFluorinationMethods0403809GreenChemistryChapter6:ProspectsandChallengesinGreenChemistryZ.Weng6.1KeyGreenChemistryResearchAreas-APerspectivefromPharmaceuticalManufacturersConstable,D.J.C.etal.GreenChem.2007,9,411.BrainstormIdeasReactionsweusenowbutwoul
4、dpreferbetterreagentsFrequencyofuseWasteassessmentProcesshazardassessmentAspirationalReactionlistKeyChallengesinPharmaManufacturingPrioritisebycompanyvoteGSKMerckPfizerLillySchering-PloughAZ0403809GreenChemistryChapter6:ProspectsandChallengesinGreenChemistryZ.WengGr
5、eenMitsunobuReactionsReductionofamidesavoidingLAHandDiboraneBrominationReactionsSulfonationreactionsAmideFormationavoidingpooratomeconomyreagentsNitrationreactionsF/CReactionsonunactivatedsubstratesDemethylationReactionsEsterHydrolysisOHactivationfornucleophillicsubs
6、titutionEpoxidationOxidationWittigChemistrywithout(Ph3PO)RadicalChemistrywithoutBu3SnHSolventlessReactorCleaningPolarAproticreplacementsforNMP,DMSO,DMAc,DMFetcAsymmetricHydrocyanationAldehydeorKetone+NH3+“X”togiveachiralamineN-Centredchemistryavoidingazideshydrazines
7、etcAsymmetricHydrolysisofnitrilesAsymmetricHydrogenationofunfunctionalisedolefins/enamines/iminesAsymmetricHydroformylationC-HactivationofaromaticsC-HactivationofalkylgroupsNewGreenFluorinationMethodsOxygenNucleophileswithhighreactivityGreensourcesofelectrophilicNitr
8、ogenAsymmetricHydroaminationofolefinsAsymmetricHydrationofolefinsOrganocatalysisROH+ArCltogiveROAr0403809GreenChemistryChapter6:Pro
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