胃癌的化学治疗（Chemotherapy of gastric cancer）.doc

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1、胃癌的化学治疗(Chemotherapyofgastriccancer)I.GeneralSituationofchemotherapyingastriccancerSurgeryisstillthemosteffectivewaytocuregastriccancer,butmostpatients(60%、70%)havealreadyhadfocalmetastasisormetastasisofadjacentimportantorgansbeforetheonsetofsymptoms,whichhasmadesurgicalresectiondiff

2、icult・Therefore,only30%“40%patientsmaybecuredbysurgeryalone,withamediansurvivalof25monthsanda5yearsurvivalrateofabout30%.Mostofthepatientsdiefromtumorrecurreneeordistantmetastasis・Chemotherapyisanimportantmeansofgastriccanceradjuvanttherapy,hasbeenwidelyusedinclinic,butnowtheoveralle

3、ffectiverateofchemotherapyofgastriccancerislow,canonlybeusedasadjuvanttherapy,whichisgenerallyusedasadjuvanttherapy・卩reoperative,intraoperativeandpostoperative,canachievethefollowingpurposes:(1)thelesionwaslimitedsoastoimprovetheresectionrate.(2)reducethechanceoftumorcelldisseminatio

4、nandimplantationduringoperation.(3)radicaladjuvantchemotherapywasperformedtoeliminatepossibleresiduallesionsinordeTtopreventmetastasisandrecurrence・(4)palliativesurgerycancontrolthedevelopmentofthediseaseandprolongthesurvivaltime・Withthefurtherstudyofgastriccancerandtheresearchanddev

5、elopmentofchemotherapeuticdrugs,thenewchemotherapystrategyandnewchemotherapeuticagentshaveshownabettertherapeuticprospect,andarebeingvalidatedbyphaseIIIandIVclinicaltrials・Anothermajorgoaloffutureclinicalresearchistoobtainmarkersthatcanpredictprognosis・Soastomaketheadjuvantchemothera

6、pyandneoadjuvantchemotherapyaccordingtoindividualdifference・Themolecularmechanismofantitumordrugsmaybedeterminedbybiochemicaltechniquestodeterminethesensitivityofthetreatment・Itisconceivablethatthechemotherapyofgastriccancerwillbemoreeffectivewithanin-depthunderstandingoftumorbiology

7、,andthefuturechemotherapyregimenwillvaryfrompersontoperson,andthelackoftreatmentorexcessivetreatmentwilldisappear・Two,theuseofchemotherapy(I)adjuvantchemotherapyforsurgeryorradiotherapyAdjuvantchemotherapyisnowreceivingattentionbecauseoftherecentdifferencesinthetimingoftumormetastasi

8、s・Atthebegin