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1、骨肽联合葡萄糖酸钙治疗骨质疏松症的临床观察［摘要］目的探讨骨肽联合葡萄糖酸钙治疗骨质疏松症的临床效果。方法选择2013年1~11月本院收治的120例骨质疏松症患者为研究对象,随机分为观察组和治疗组各60例，对照组患者给予非笛体消炎镇痛药物和钙剂口服，同时给予补充维生索D。观察组患者在对照组治疗基础上给予骨肽(50mg)+250ml0.9%NaCl注射液以及葡萄糖酸钙(10%,20ml)+250ml5%葡萄糖注射液静脉滴注，治疗2个月后观察比较两组患者的骨痛改善情况、腰椎和左侧股骨颈骨密度的变化情况。结果观
2、察组患者治疗总有效率(90.00%)明显高于对照组(56.67%),差异有统计学意义(P<0.05)；观察组治疗后腰椎L2~4骨密度水平为(0・78土0・10)g/cm2,左侧股骨颈骨密度水平为(0・58±0・02)g/ciTi2,均明显高于对照组，差异有统计学意义(P<0.05)；两组不良反应发生率差异无统计学意义(P>0.05)o结论骨肽联合葡萄糖酸钙治疗骨质疏松症效果较好，能有效改善骨痛，提高骨密度，值得临床推广应用。［关键词］骨肽；葡萄糖酸钙；骨质疏松症［中图分类号］R681E文献标识码］A［文章
3、编号］1674-4721(2014)05(b)-0085-03ClinicalobservationofthebonepeptidejointcalciumgluconateintreatmentofosteoporosisMOZu-shuangTheFirstDepartmentofInternalMedicine,People^sHospitalofXingyeCountyinGuangxiZhuangAutonomousRegion,Xingye537800,China[Abstract]Objec
4、tiveToinvestigatetheclinicaleffectofbonepeptidejointcalciumgluconateinthetreatmentofosteoporosis.Methods120casesofpatientswithosteoporosisinourhospitalfromJanuarytoNovember2013weredividedintocontrolgroup(60cases)andobservationgroup(60cases),thecontrolgrou
5、pweretreatedbynon一steroidalanti一inf1animatorydrugs,oralcalciumandvitaminDsupplements;theobservationgroupweretreatedbyossotide(50mg)+250ml0.9%NaClandcalciumgluconateinjection(10%,20ml)+250ml5%glucoseintravenousinjectiononthebasisofcontrolgroup・Theimproveme
6、ntofbonepain,lumbarspineandleftfemoralneckbonemineraldensitychangesincircumstancesoftwogroupswereanalyzed.ResultsThetotaleffectiverateoftheobservationgroup(90.00%)wassignificantlyhigherthanthatofthecontrolgroup(56.67%),thedifferencewassignificnat(P<0・05).
7、Bonemineraldensityofthe1umbarspineL2~4levelswas(0.78+0.10)g/cm2andtheleftfemoralneckbonemineraldensitylevelswas(0.58+0.02)g/cm2oftheobservationgroup,whichwasrespectively,thedifferencewassignificnat(P<0.05).Adversereactionrateofthetwogroupshadnosignificant
8、difference(P>0.05)・ConclusionTheefficacyofbonepeptidejointcalciumgluconatetreatingosteoporosisiswell,itcaneffectivelyimprovebonepainandincreasebonemineraldensity,isworthusinginclinic・［Keywords］Bonepeptide;Calciumglu
