冠状病毒Coronavirusl论文-2009 FIP and coronavirus 7b protein antibodies.pdf

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1、PAGE4ADVANCESInclusionsTwofigures,1table,17references.FIPANDCORONAVIRUS7bEditorAnnotationPROTEINANTIBODIESFIPremainsanenigma.PresenceofthecoronavirusisnotconsistentwiththeBackgrounddevelopmentofFIP.TheabilitytomakeFelineInfectiousPeritonitis(FIP),causedthisdiagnosisinacatwithoutef

2、fusivebyafelinecoronavirus,canoccurasanclinicalsignsisgoingtotakeamassiveeffusiveperitonitisorpleuritiswithagraveamountofadditionalstudy.Thisstudyprognosis.Alternatively,amorechronicconfirmsthatfact.Experienceinourdiag-coursewithgranulomatous(“dry”)lesionsnosticlaboratoryhasconfir

3、medthattheoccurs,affectingmultipleorgans.Thisgoldstandardfordiagnosisrequireshis-alsohasagraveprognosis.Theearly,topathologyanddemonstrationofthenon-invasivediagnosisofFIPisdifficult.coronavirusantigenviaimmunohisto-chemistrystainingininflamedtissue.ObjectivesTheseauthorswerehopin

4、gthatthisTodeterminewhetherthepresenceofspecificproteinantibodywouldbeconfir-felinecoronavirus(FCoV)7bproteincon-matoryforthedisease.Theyfound,ashassistentlycorrelateswiththeoccurrenceofbeenconfirmedwithPCRtesting,thattheFIPincats.FIP-associatedcoronavirusispresentinahighpercentag

5、eofcatswithoutFIP.Iden-ProceduretificationoftheantibodyorantigeninaNinety-fiveserumsamplesfromcatswithcatdoesnotalwayscorrelatewithdisease.FIPweresubmittedtothelaboratoryforThediseasemostlikelyisacombinationvariousdiagnosticassays,and20samplesthevirus,eithergeneticallymodifiedorfr

6、omspecific-pathogen-freecatswerethestreetvirus,reactinginacatwithtestedasnegativecontrolsamples.theappropriateimmunologicorinnateThe7bgenefromavirulentstrainofimmunityinteractiontoresultindisease.FCoVwasusedinantibodydetectionInotherwords,likeotherconditionsinassaysusingwesternblo

7、tanalysisofserumsamples.Resultswerecomparedthecat,itrequiresthecat’simmunityandwiththoseofanimmunofluorescencevirusinteractiontobecomepathogenic.assay(IFA)forFCoV-specificantibodyTheviruswithoutanimbalancedimmuno-andcorrelatedwithclinicalsigns.logicalreactioninthecatislikelytoresi

8、dewithoutanypathogenicresults.Res