器官移植的发展与未来.ppt

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1、器官移植的發展與未來台北榮總一般外科龍藉泉Humanchimera,or“homonovo.”Man’soriginalstructurehasbeenmodifiedsothathecanacceptanorgan“fromelsewhere”MythandLegendMythandLegendMythandLegendMythandLegendProf.V.Demikhovandhistwo-headeddog.phototakentwodaysaftertheoperationU.S.S.R(1950)MA

2、INSTEPSINGRAFTHISTORYTHEPLANTGRAFT:VERYEARLYINMAN’SHISTORYTHEANIMALGRAFT:18THCENTRURYTHEHUMANGRAFT:18THCENTURYORGANTRANSPLANTATION:20THCENTURYFROMGARDENTOFARMYARDFROMGARDENTOFARMYARD19THCENTURY:ALLFROMSOFGRAFTSBoronio’ssheep(1804).Successfulreplacementskingra

3、ftsonthebackofanewe.PaulBertnexttoClaudeBernard,performingavivisectionprocedureinhislaboratoryattheCollegeofFrancein1889.Freesplit-skingraftonaburnoftheshoulderandarm.THEKIDNEY:APILOTORGANTHEFIRSTTRANSPLANTATIONINANIMALAttheViennaMedicalSocietymeetingheldinJa

4、nuary1902,thesurgeonEmerichUllmannreportedthefirstcaseofrenaltransplantationperformedintheneckofadog.Theureter,broughtouttotheskin,oozeda“liquidwhichresembleurine”overaperiodoffivedays.Dr.AlexisCarrel–AmagicianFirstrenaltransplantationsinman:1906-1913In1906,M

5、athieuJaboulayperformedrenaltransplantationinman.Hetransplantedtheleftkidneyofapig,killed3hourspreviously,intotheleftelbowofawomansufferingfromnephroticsyndrome.Thegraftremovedonthethirddayandthevesselswerefoundtobeobstructedbyclots..Firsttransplantationbetwe

6、enhumans:1933In1933,therussiansurgeonVoronoy(1896-1961)performedthefirsthomologousrenaltransplantationinmanusingahumancadaverkidney.SergeVoronoff,attheCollègedeFrance.Testiculartransplantationfromamonkeytoman.Aretiredindianarmycolonelinfineformaftertheoperati

7、on.TheBrighamcommando:1947Ayoungwomanwasinprofoundcomawithanuriafor10daysfollowinganabortioncomplicatedbyacutetubulopathyduetosepticshockandincompatibletransfusion.DavidM.Hume(1917-1973)Paris,Christmas1952:thepresentfromamothertohersonMrsRenardandhersonMarius

8、towhomshedonatedakidneyinDecember1952.Pelvicimplantationofthekidneywithrestorationoftheurinarytract.ArealSuccess:1954JohnMerrillandJosephMurry(NobelPrize1991)attheBrighamin1953Firstsuscce