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1、LehningerPrinciplesofBiochemistryFourthEditionDavidL.Nelson(U.ofWisconsin–Madison)MichaelM.Cox(U.ofWisconsin–Madison)1.TheFoundationsofBiochemistry1.1CellularFoundations1.2ChemicalFoundations1.3PhysicalFoundations1.4GeneticFoundations1.5EvolutionaryFoundationsDistilledandreorganize
2、dfromChapters1–3ofthepreviousedition,thisoverviewprovidesarefresheronthecellular,chemical,physical,genetic,andevolutionarybackgroundtobiochemistry,whileorientingstudentstowardwhatisuniqueaboutbiochemistry.PARTI.STRUCTUREANDCATALYSIS2.Water2.1WeakInteractionsinAqueousSystems2.2Ioniz
3、ationofWater,WeakAcids,andWeakBases2.3BufferingagainstpHChangesinBiologicalSystems2.4WaterasaReactant2.5TheFitnessoftheAqueousEnvironmentforLivingOrganismsIncludesnewcoverageoftheconceptofprotein-boundwater,illustratedwithmoleculargraphics.3.AminoAcids,Peptides,andProteins3.1AminoA
4、cids3.2PeptidesandProteins3.3WorkingwithProteins3.4TheCovalentStructureofProteins3.5ProteinSequencesandEvolutionAddsimportantnewmaterialongenomicsandproteomicsandtheirimplicationsforthestudyofproteinstructure,function,andevolution.4.TheThree-DimensionalStructureofProteins4.1Overvie
5、wofProteinStructure4.2ProteinSecondaryStructure4.3ProteinTertiaryandQuaternaryStructures4.4ProteinDenaturationandFoldingAddsanewboxonscurvy.5.ProteinFunction5.1ReversibleBindingofaProteintoaLigand:Oxygen-BindingProteins5.2ComplementaryInteractionsbetweenProteinsandLigands:TheImmune
6、SystemandImmunoglobulins5.3ProteinInteractionsModulatedbyChemicalEnergy:Actin,Myosin,andMolecularMotorsAddsanewboxoncarbonmonoxidepoisoning6.Enzymes6.1AnIntroductiontoEnzymes6.2HowEnzymesWork6.3EnzymeKineticsasAnApproachtoUnderstandingMechanism6.4ExamplesofEnzymaticReactions6.5Regu
7、latoryEnzymesOffersarevisedpresentationofthemechanismofchymotrypsin(thefirstreactionmechanisminthebook),featuringatwo-pagefigurethattakesstudentsthroughthisparticularmechanism,whileservingasastep-by-stepguidetointerpretinganyreactionmechanismFeaturesnewcoverageofthemechanismforlyso
8、zymeincludingthecontrovers
