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1、第15卷第2期地方病通报Vol.15,No.22000年5月ENDEMICDISEASESBULLETINMay,2000ArticleID:1000-3711(2000)02-0069-04ReappraisalofMebendazole(Vermox)EfficacyforTreatmentofCysticEchinococcosis(Ananalysisof12Cases)JIANGCi-peng(HydatidosisResearchLaboratory,LanzhouMedicalCollege,Lanzhou,Gansu730000,Chin
2、a)Abstract:Thispaperobservedclinicallytheefficacyofmebendazole(Vermox)inthetreatmentof12caseswithcysticechinococcosis(CE).Among12cases,6wereliverCE,4lungCE,and2liver-lungCE.Thedailydosewas500mgonetimet.i.d..inadultsanddecreasedappropriatelyinchildren.Onetherapeuticcourselasted30da
3、ysandatleastthreecourseswereadministeredinthisseries.Acomparisionoftheimagingexaminationswasmadebetweenpre-andpost-treatment.ChestX-rayfilmandultrasonicscanningwereadoptedrespectivelyinlungCEandinliverCE.Outof12cases,2werecured(16.7%),8improved(72.7%),and2failed(16.6%).Anysidereac
4、tionswasnotfoundineverypatient.Theaboveresultsshowedthatmebendazole(Vermox)wasstillaneffectivedruginthetreatmentofcysticechinococcosis.Keywords:Mebendazole(Vermox);Cysticechinococcosis;TreatmentCLCnumber:R532.32;R453Documentcode:AChemotherapyofechinococcosisbegantoriseyears),andon
5、lyoneasoldas58years.Of7casesover20years.Mebendazole(MBZ)wasclinicallywithliverCE,3weremultiplecystsand4singleusedearlier,butlatelyitwasreplacedbyalbendazolecyst.Of5caseswithlungCE,3weresinglecystand(ABZ)overonedecade.Thesetwodrugsbelonged2multiplecysts.tothederivativesofbenzimidaz
6、olesandWHO1.2Thedosageandthetherapeuticcourse:Theconsideredthemasthefirst-selectedremediesforthedosewas500mgonetimet.i.d.inadultsandtreatmentofechinococcosis.Underthepresentdecreasedappropriatelyinchildren.AtherapeuticsituationofusingABZtotreatnearlyallthepatientscourselasted30day
7、s.Atleast3courseswereofechinococcosisathomeandabroad,MBZoughtadministeredgenerally,andVermoxwastakenasnottobegivenupcompletely.Sothat,themanyas22coursesinonepatientofcomplicatedCE.therapeuticefficacyof12CEcaseswithmebendazole1.3Thedeterminationofthetherapeuticefficacy:(Vermox,prod
8、uctfromBelgiumJanssenAccordingtot